ArticleEuropean journal of medical research2025
Real-world experience of hetrombopag in immune thrombocytopenia treatment: a retrospective cohort study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- [Chinese guideline on the diagnosis and treatment of adult primary immune thrombocytopenia (2025)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Guideline
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical data on hetrombopag, a novel thrombopoietin receptor agonist (TPO-RA) developed in China, remain limited for the treatment of immune thrombocytopenia (ITP). This retrospective study aimed to investigate the efficacy and safety of hetrombopag for ITP patients in the real-world setting.
methodsPatients with ITP received hetrombopag monotherapy at an initial dose of 2.5 mg or 5.0 mg once daily. The primary endpoint was the proportion of responders whose platelet count ≥ 50 × 10
resultsA total of 50 ITP patients were enrolled. The median time to response was 7 days; the mean platelet count increased from 16 × 10⁹/L at baseline to 104 × 10⁹/L at week 12; the response rate was 71% at week 12. The 5 mg/d group showed significantly better efficacy as early as week 2 compared with the 2.5 mg/d group (P < 0.05). Among 15 nonresponders in the 2.5 mg group, 11 patients were switched to the 5 mg group, and 6 of them then achieved response. The clinical response was reached in 7 of 8 ITP patients switching from eltrombopag to hetrombopag. There was no difference in the overall response rate between patients receiving hetrombopag as a second-line therapy and later-line therapies (P = 0.951). No serious adverse events were observed. In addition, the total number of megakaryocytes in the bone marrow was positively associated with treatment efficacy at week 4 (P = 0.001).
conclusionsHetrombopag was effective and safe in the real-world treatment of ITP. An initial dosage of hetrombopag 5 mg/d and a higher megakaryocyte count in bone marrow may predict better therapeutic efficacy.
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