ArticleBMC musculoskeletal disorders2025
Efficacy of hydrolyzed collagen injections compared to platelet-rich plasma and hyaluronic acid in the treatment of patients with symptomatic knee osteoarthritis: a retrospective clinical study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Comparative efficacy of ultrasound-guided intra-articular injection of platelet-rich plasma (PRP), hydrolyzed type I collagen, and hyaluronic acid in patients with knee osteoarthritis: a randomized controlled trial.Future science OA · 2026Article
- Comparative Short-Term Clinical Outcomes of Hybrid Hyaluronic Acid and Platelet-Rich Plasma Injections in Knee Degenerative Conditions: An Exploratory Real-World Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Clinical efficacy and safety of ultrasound-guided injection with low-molecular-weight peptides from hydrolyzed collagen in patients with first carpometacarpal joint osteoarthritis.Frontiers in medicine · 2026Article
- Videos in short-video sharing platforms as sources of information on osteoarthritis: cross-sectional content analysis study.Frontiers in digital health · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesHydrolyzed collagen (CHG) is an emerging infiltrative therapy for the treatment of osteoarthritis. The objective of this retrospective study was to compare its effectiveness with that of hyaluronic acid (HA) and platelet-rich plasma (PRP).
methodsThe Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of 72 patients with Kellgren-Lawrence grade 1-4 osteoarthritis were recorded and analyzed over a 12-month follow-up period. Patients received either three CHG injections, a single HA injection, or three PRP injections and the results were compared. Of the participants, 23 were treated with CHG, 25 with HA, and 24 with PRP.
resultsTreatment effectiveness was assessed at 3, 6, and 12 months. At the 12-month follow-up, the CHG group showed a 56% improvement in the WOMAC total score, compared to 22.5% for the HA group and 47% for the PRP group. Pain reduction was also greatest in the CHG group, with a 52% decrease at 12 months, versus 16% in the HA group (p < 0.05).
conclusionsIn this retrospective study, CHG demonstrated a more sustained therapeutic effect in terms of pain relief and functional improvement compared to HA and PRP over a one-year period. No side effects were observed in any of the treatment groups.
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