Evidence map›Paper›PMID 40616005›Full record

ArticleBMC pregnancy and childbirth2025

The impact of pre-pregnancy overweight/obesity on the birth weight of offspring born from women with polycystic ovarian syndrome.

Jiejing Jiao, Yiyuan Zhang, Jiayi Zhou, Rui Lv, Linlin Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiejing Jiao *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 247 Beiyuan Road, Jinan, 250012, China.
Yiyuan Zhang *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 247 Beiyuan Road, Jinan, 250012, China.
Jiayi ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 247 Beiyuan Road, Jinan, 250012, China.
Rui LvState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 247 Beiyuan Road, Jinan, 250012, China.
Linlin CuiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 247 Beiyuan Road, Jinan, 250012, China. fdclear3@126.com.

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-5-001Fundamental Research Funds of Shandong University 2023QNTD004National Key Technology Research and Developmental Program of China 2022YFC2704404Shandong Provincial Natural Science Foundation ZR2022JQ33
6 · The paper itself

Abstract

objectivesThe purpose of our study is to explore whether polycystic ovary syndrome (PCOS) has an independent impact on the neonatal birth weight (BW), and whether pre-pregnancy overweight/obesity plays a mediating role on the association between PCOS and neonatal BW.

methodsThis nested case-control study included singletons born to mothers who were treated with ART at the Center for Reproductive Medicine, Shandong Provincial Hospital affiliated with Shandong University during the period from January 1, 2008, to December 31, 2019. Propensity score matching (PSM) was used to match the following independent variables to minimize the influence of confounding factors: paternal body mass index (BMI), parental age, gender of offspring. The Generalized estimating equation (GEE) model was performed to compare the outcomes. The mediation model was used to evaluate the intermediary effect of pre-pregnancy BMI. Restricted cubic spline (RCS) logistic regression was used to analyze the non-linear associations between pre-pregnancy BMI and infants BW.

resultsAfter PSM, 1678 and 6712 singletons were included in the PCOS group and the non-PCOS, respectively. After adjusting for confounders of offspring, parents, assisted reproductive technology (ART) and family socio-economic status, the PCOS group had higher BW Z-score, BW/ length (L), BW/L

conclusionsIt was overweight/obesity, along with abnormal glycolipid metabolism, rather than PCOS itself, that contributed to an abnormally increased BW in their offspring.

Indexed as

Birth WeightObesityOverweightPolycystic Ovary SyndromePregnancy ComplicationsAdultBody Mass IndexCase-Control StudiesChinaFemaleHumansInfant, NewbornMalePregnancyBirth weightBody mass indexLarge for gestational ageOverweight/obesityPolycystic ovary syndrome

Identifiers

PMID40616005
PMCPMC12231976

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.