ArticleBMC pulmonary medicine2025
The higher serum uric acid to high-density lipoprotein cholesterol ratio is associated with increased risk of chronic obstructive pulmonary disease: result from NHANES 2011-2018.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Article
- Mendelian Randomization Study in East Asian Populations Supports the Causal Relationship Between Blood Metabolites and COPD: Insights from Amino Acids, Phospholipids, Vitamin D, and Trace Elements.International journal of chronic obstructive pulmonary disease · 2026Article
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Admission uric acid to HDL-C ratio predicts 90-day post-stroke depression in acute ischemic stroke.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInflammation plays a significant role in the emergence and progression of chronic obstructive pulmonary disease (COPD). Uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel metabolic biomarker that is associated with the risk of inflammation. This study aimed to assess and evaluate COPD by calculating UHR.
methodsThe cross-sectional research utilized information from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2011 to 2018. To explore the link between UHR and COPD, a multivariate logistic regression analysis was conducted. In addition, effect analysis, smooth curve fitting, the receiver operating characteristic (ROC) curve analysis, Kaplan-Meier survival analysis, subgroup analysis, mediation analysis and sensitivity analysis were used to further explore the association between UHR and COPD.
results688 patients were diagnosed with COPD among 9467 participants. After adjusting for interfering factors, logistic regression analysis revealed a notable correlation between UHR and COPD. Smooth curve fitting indicated a linear association between UHR and COPD. In addition, factors such as gender, smoking status, and hypertension were significantly associated with COPD. ROC curve analysis showed that the diagnostic accuracy of UHR was higher than that of Uric acid (UA) and High-density lipoprotein cholesterol (HDL-C). Higher UHR levels were associated with reduced survival. Subgroup analyses showed that gender, smoking status, and hypertension modified the association between UHR and COPD incidence. Mediation analyses identified C-reactive protein (CRP), triglycerides (TG) and phosphorus as potential mediators between UHR and COPD.
conclusionsThis research uncovered a notable correlation between UHR and COPD. These findings suggested that UHR could be a potential indicator for early diagnosis and intervention during COPD progression.
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Registered trials
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