Evidence map›Paper›PMID 40616270›Full record

ArticlePhysiological reports2025

The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice.

Casey L Egan, Atanaska Doncheva, Martin Pal, Sarah L Fox, Knut Tomas Dalen, Martin Whitham, Mark A Febbraio, Marit Hjorth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Casey L EganDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Atanaska DonchevaDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Martin PalGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Sarah L FoxGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Knut Tomas DalenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Martin WhithamGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Mark A FebbraioDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Marit HjorthGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8067-714X

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1041760Department of Health | National Health and Medical Research Council (NHMRC) APP1042465Direktør Throne Holsts Fond For Ernæringsforskning (Throne-Holst Foundation for Nutrition Research)
6 · The paper itself

Abstract

Physical activity is associated with improvements in insulin sensitivity and muscle function. The proteoglycan decorin is increased in skeletal muscle and plasma in response to exercise, but the biological implications are unknown. We investigated the effects of decorin deficiency on obesity, glucose tolerance, and exercise adaptation in C57BL/6J mice. Decorin deficiency did not influence adiposity, insulin- and glucose- tolerance, or energy metabolism in obese, high fat diet fed mice (Dcn

Indexed as

AdiposityDecorinObesityPhysical Conditioning, AnimalAnimalsBlood GlucoseDiet, High-FatEnergy MetabolismGlucose IntoleranceInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalBlood GlucoseDcn protein, mouseDecorindecorinexerciseextracellular matrixmyokinesobesity

Identifiers

PMID40616270
PMCPMC12227656

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.