ArticleJournal of surgical oncology2025
Less Is More: Risk Factors and Survival Outcomes of Overtreatment for Early-Stage Colorectal Cancer.
Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A new paradigm in postoperative colorectal cancer surveillance: integrating advanced imaging and multi-omics.Frontiers in physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectivesAfter cT1-2N0M0 colorectal cancer (CRC) definitive resection (colectomy/proctectomy) without pathologic upstaging, only observation is recommended given the lack of benefit from adjuvant treatment, which would constitute overtreatment. This study aims to determine risk factors and overall survival (OS) associated with overtreatment in early-stage CRC.
methodsThis National Cancer Database study included cT1-T2N0M0 CRC patients who underwent definitive resection between 2010 and 2020. Multivariable logistic regressions were performed to assess overtreatment risk factors. After propensity-matching, Kaplan-Meier survival analyses and multivariable Cox proportional-hazards analyses were performed to assess the association of overtreatment with OS.
resultsOf 22 875 colon cancer and 4198 rectal cancer cases, 144 (0.6%) and 82 (2.0%) were overtreated, respectively. Colon cancer overtreatment was associated with younger age (aOR = 0.96, 95% CI = 0.95-0.98), Black race (aOR = 1.94, 95% CI = 1.26-2.99), and pT2 vs. pT1 (aOR = 1.66, 95% CI = 1.19-2.33). Rectal cancer overtreatment was associated with pT2 (aOR = 2.58, 95% CI = 1.59-4.19), poor/undifferentiated grade (aOR = 2.61, 95% CI = 1.44-4.76), and high-risk histology (aOR = 3.20, 95% CI = 1.22-8.40). In the propensity-matched cohorts, overtreatment was associated with worse OS for colon (HR = 1.40, 95% CI = 1.01-1.93) but not rectal cancer (HR = 1.05, 95% CI = 0.66-1.68).
conclusionsPatient and tumor characteristics predicted early-stage CRC overtreatment. Overtreatment was associated with worse OS for colon but not rectal cancer.
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Registered trials
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