ArticleAnnals of medicine2025
Gut frailty: the core of reversing frailty.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Gut-Brain-Muscle Axis: Microbial Regulation of Neuromuscular Aging and Cognitive Frailty.Microorganisms · 2026Review
- Gut frailty in chronic heart failure: clinical determinants and distinct microbial signatures.Frontiers in cardiovascular medicine · 2026Article
- Preoperative nutritional status, frailty, and postoperative delirium in patients undergoing pancreatic cancer surgery: a prospective observational study.Frontiers in nutrition · 2026Article
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imbalances in gut microbiota have been implicated in numerous age-related degenerative diseases and unhealthy aging. Frail individuals often exhibit severe malnutrition and gastrointestinal dysfunction. Recent studies have demonstrated a correlation between physical frailty, cognitive decline, gastrointestinal function, and intestinal microbiota, leading to the introduction of the concept of 'gut frailty'. However, the mechanisms by which intestinal weakness influences frail individuals and contributes to the onset of frailty remain unclear. We hypothesize that gut frailty encompasses not only the deterioration of gastrointestinal function but also the ecological imbalance of gut microbiota, which disrupts the normal aging process. This condition may impact frailty through several critical pathways, particularly those involving the gut-brain and gut-muscle axes, and constitutes a central and essential factor in the development of frailty. This perspective suggests the potential of targeting gut frailty as a therapeutic strategy in the context of Geroscience, highlighting its role beyond mere participation in the frailty process.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.