ReviewCurrent microbiology2025
Functional RNA Elements in Alphavirus Genomes.
Review in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Overview of Chikungunya Virus Epidemiology, Biology, and Pathogenesis.Methods in molecular biology (Clifton, N.J.) · 2027Review
- Optimized Amplicon Strategy for Long-Read Sequencing of the Chikungunya Virus Genome.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Transgene sequence codon optimization and composition determines replication competence of self-amplifying RNA.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Ewing sarcoma breakpoint region 1 (EWSR1) protein binds to nonstructural protein 2 and non-coding regions of chikungunya virus genome to inhibit virus replication.Journal of virology · 2026Article
- Review
- Current perspectives on alphavirus encapsidation, assembly and budding.Frontiers in cellular and infection microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Alphaviruses are members of the Togaviridae family and comprise important human reemergent pathogens. They have positive-sense RNA genomes encoding both structural and non-structural proteins. Additionally, their genomes harbor diverse cis-acting RNA elements that accumulate functional information. Sequence and structural features are crucial for regulating replication, transcription, translation, and encapsidation. This review explores the multifunctional roles of these RNA elements, emphasizing their contribution to virus-host interactions, pathogenesis, and evolutionary adaptability. Key features include the 5'stem-loop and downstream elements, the subgenomic promoter, several packaging signals, a translation enhancer, the transframe and opal codons, and the 3'untranslated region. These elements collectively orchestrate the alphavirus life cycle and counteract host antiviral responses. Comparative analyses reveal structural and functional diversity across alphavirus species, reflecting evolutionary pressures from both vertebrate and invertebrate hosts. Understanding viral RNA elements provides critical insights into alphavirus molecular biology and opens new avenues for potential therapeutic strategies targeting conserved viral features.
Indexed as
Identifiers
40616665What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.