ArticleBiological trace element research2025
Linalool May Exert Neuroprotective Effects Against Cadmium-Induced Hippocampal Neurodegeneration by Regulating the 4-HNE/NF-κB Signaling Pathway.
Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Dynamic changes in OTULIN and progranulin levels in experimental myocardial infarction and cardiac remodeling.Histochemistry and cell biology · 2026Article
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Understanding molecular mechanisms driving cadmium-induced mitochondrial dysfunction in human metabolic liver disease.Environmental toxicology and pharmacology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a prevalent industrial and environmental contaminant that accumulates in the tissues of animals and humans. In particular, one of the regions most affected by Cd-induced neurodegeneration is the hippocampus. Linalool (Lin) is a monoterpene capable of traversing the blood-brain barrier owing to its low molecular weight and high lipophilicity. This study sought to establish the possible neuroprotective effects of Lin against Cd-induced hippocampal neurodegeneration by focusing on the 4-hydroxynonenal (4-HNE)/Nuclear factor kappa B (NF-κB) signaling pathway. The 28 male rats used in the experiment were randomly (n = 7) distributed into four groups. The control group was not administered. The Cd group received CdCl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.