Trial reportTranslational psychiatry2025
Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial.
Trial report in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02807480 (Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response
Who cites it
2 citing papers in PubMed.
- Human approach-avoidance conflict behaviour relates to transdiagnostic psychiatric symptom dimensions.Translational psychiatry · 2026Article
- Physical activity moderates the relationship between PTSD symptom severity and approach-avoidance conflict decision-making.Journal of anxiety disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Treatments for generalized anxiety disorder (GAD) often aim to address maladaptive approach-avoidance behavior patterns. Approach-avoidance conflict (AAC) offers a potential framework for identifying treatment outcome predictors and informing optimization of GAD treatment. The current study examined whether pre-treatment neurobehavioral AAC indices predict symptom improvement in behavioral activation (BA) and exposure therapy (EXP) for GAD. Treatment-seeking adults meeting criteria for GAD completed a randomized clinical trial with pre-treatment blinding, conducted from 2016-2021. Participants were randomized to complete 10 manualized sessions of BA or EXP. Participants completed an AAC task during functional magnetic resonance imaging pre-treatment. Computational parameters of task behavior were derived, and neural activity was assessed during decision-making and positive and negative outcomes of decisions. Outcome measures were GAD symptoms and depressive symptoms. Of 121 participants recruited, 56 (29 BA, 27 EXP; mean age 33.0 years; 12.5% male) treatment completers were included in analyses. Greater AAC task avoidance (d = -0.28) and greater left dorsolateral prefrontal cortex activation during negative outcomes (d = -0.32), predicted greater symptom reduction across treatments. Blunted left amygdala activation to positive outcomes was associated at a trend level with favorable symptom reduction for BA but not EXP (d = -0.20). The dorsolateral prefrontal cortex may be a target for enhancing behavior therapy outcomes generally, while left amygdala activation to positive affect may be a target for enhancing outcomes for BA. These findings may inform the optimization of behavioral therapies for GAD and hold potential for transdiagnostic applications, warranting larger, longitudinal studies in clinical settings. Clinical Trials Registration: ClinicalTrials.gov NCT02807480.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.