Evidence map›Paper›PMID 40618019›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination.

Hongzhou Liu, Xiaodong Hu, Tan Li, Yuhan Wang, Xiaomin Fu

Abstract read
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In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hongzhou Liu *Department of Endocrinology, First Hospital of Handan City, Handan, 056002, Hebei Province, China.
Xiaodong Hu *Department of Endocrinology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Tan LiDepartment of Endocrinology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Yuhan WangDepartment of Endocrinology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Xiaomin FuClinics of Cadre, Department of Outpatient, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. fuxiaomin@301hospital.com.cn.

Funding

Hebei Natural Science Foundation H2021109008
6 · The paper itself

Abstract

backgroundTripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear.

methodsHuman study and animal experiments were performed. Mass spectrometry, cellular invasion/metastasis assay, chemo-resistance assay, and ubiquitination evaluation were conducted to investigate the interaction between TRIM47 and adenosine deaminases acting on RNA (ADAR).

resultsTRIM47 expression was increased in human tissues and cell lines of TC. Functional experiments demonstrated that TRIM47 expression enhanced malignant biological behaviors. With mass spectrometry, TRIM47 silencing could significantly decrease the chemo-resistance of TC cells to chemotherapeutic drugs. The interaction between TRIM47 and ADAR was mediated through the ubiquitin-proteasome pathway (UPP), which was approved by RNA interference procedure and co-immunoprecipitation.

conclusionComprehensively, glycogen synthase kinase-3β (GSK-3β)-associated ubiquitination is critical in the TRIM47-ADAR-GSK-3β axis. This study demonstrates that TRIM47 interacted with ADAR to facilitate ADAR protein degradation via ubiquitination and GSK-3β-associated phosphorylation, which serves as a novel therapeutic avenue for TC.

Indexed as

Adenosine DeaminaseRNA-Binding ProteinsThyroid NeoplasmsTripartite Motif ProteinsUbiquitinationAnimalsCell Line, TumorGene Expression Regulation, NeoplasticGlycogen Synthase Kinase 3 betaHumansMiceProteolysisADAR protein, humanAdenosine DeaminaseGlycogen Synthase Kinase 3 betaRNA-Binding ProteinsTripartite Motif ProteinsAdenosine deaminases acting on RNAGlycogen synthase kinase-3βPhosphorylationThyroid carcinomaTripartite motif 47Ubiquitination

Identifiers

PMID40618019
PMCPMC12229022

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.