ArticleBMC cardiovascular disorders2025
Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Development and validation of a prediction model for ischemic stroke recurrence risk in patients with ischemic stroke and atrial fibrillation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Temporal trends of atrial fibrillation and atrial flutter burden across the BRICS: An observational study analysis for the GBD 2021.Medicine · 2026Observational
- Racial and ethnic disparities in the management of risk factors in individuals with atrial fibrillation: A narrative review.American journal of preventive cardiology · 2026Review
- The Global Burden and Trends of Premenopausal Breast Cancer by Modifiable Lifestyle Factors From 1990 to 2021 With Prediction Until 2039.Global health, epidemiology and genomics · 2026Article
- Correction: Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021.BMC cardiovascular disorders · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study comprehensively examines the global burden of atrial fibrillation and atrial flutter (AF/AFL) attributable to high alcohol use from 1990 to 2021, analyzing temporal trends, regional disparities, and sociodemographic determinants using data from the Global Burden of Disease Study 2021 (GBD 2021).
methodsWe extracted GBD 2021 estimates on deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for AF/AFL due to high alcohol use across 204 countries. Joinpoint analysis and age-period-cohort (APC) modeling were employed to assess temporal trends and disentangle age, period, and cohort effects.
resultsIn 2021, AF/AFL attributable to high alcohol use contributed to 11,908 deaths (95% UI: 8,860, 14,981) and 362,698 DALYs (95% UI: 263,321, 465,594) globally, marking increases of 176.4% and 132.9%, respectively, since 1990. While age-standardized death rates (ASDR) remained stable (0.2 per 100,000), males bore 2.3-fold higher mortality and 3.7-fold greater DALYs than females. Western Europe had the highest burden (4,589 deaths; 109,934 DALYs), while Oceania reported the lowest (2 deaths; 68 DALYs). High Socio-Demographic Index (SDI) regions exhibited the largest absolute burden, yet low-middle SDI regions experienced the steepest ASDR growth (estimated annual percentage change (EAPC) of ASDR is 2.01%). APC models revealed diverging sex-specific trends: male mortality marginally increased (net drift = 0.091%/year) versus significant female declines (-0.925%/year). The mortality rates are notably elevated in the age groups of 30-39 and those over 75 years, with the highest peak observed in individuals aged 95 and above.
conclusionAF/AFL attributable to high alcohol use remains a critical public health challenge, disproportionately affecting males, high-SDI regions, and aging populations. Targeted interventions addressing alcohol consumption patterns, gender-specific risk mitigation, and healthcare disparities are urgently needed to reduce the growing burden, particularly in regions with accelerating trends.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.