ArticleBMC nutrition2025
Sesame oil improves biomarkers of glycemic control in women with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, controlled clinical trial.
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimThis study aimed to investigate whether sesame oil (SO) consumption could improve biomarkers of glycemic control, inflammation, and oxidative stress in women with metabolic dysfunction-associated steatotic liver disease (MASLD).
methodsThis randomized, double-blind, controlled trial included 60 women with MASLD (aged 20-50 years, body mass index (BMI) 25-40 kg/m²) assigned to either SO or sunflower oil (SFO) group (n = 30 each), who consumed 30 g/day for 12 weeks alongside a 500 kcal/day calorie-restricted diet. Serum fasting blood glucose (FBG), fasting serum insulin (FSI), homeostatic model assessment for insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), serum high-sensitivity C-reactive protein (hs-CRP), and serum malondialdehyde (MDA) were measured at the pre- and post-intervention phases.
resultsCompared with the control, SO supplementation led to significant improvements in FBG (mean difference: -18.2 mg/dL; 95% confidence interval (CI): -25.0 to -11.4; Cohen's d = 0.84), FSI (-3.2 µIU/mL; 95% CI: -4.5 to -1.9; d = 0.76), HOMA-IR (-1.4; 95% CI: -2.0 to -0.8; d = 0.81), HOMA-β (+ 15.6; 95% CI: +7.4 to + 23.8; d = 0.67), and QUICKI (+ 0.07; 95% CI: +0.03 to + 0.11; d = 0.72) (p < 0.05 for all). The reductions in hs-CRP (-0.05 mg/dL; 95% CI: -0.15 to + 0.05; d = 0.12) and MDA (-0.6 µmol/L; 95% CI: -1.4 to + 0.2; d = 0.28) were not significant (p > 0.05). Both groups presented significant weight loss, with no significant difference between them (p > 0.05).
conclusionsSO consumption significantly improved glycemic control biomarkers in women with MASLD, suggesting potential metabolic benefits beyond weight loss.
trial registrationThis study was approved by the Institutional Review Board of Isfahan University of Medical Sciences (code: IR.MUI. RESEARCH: REC.1399.548), and it is registered at https://www.irct.ir/trial/52288 , IRCT20140208016529N6, Registration Date: 2020-12-12).
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