ArticleBMC biology2025
Genome-wide identification of the interferon complex establishes IFNf in Cypriniformes.
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide.PLoS pathogens · 2026Article
- A decoy receptor antagonizes interferon mediated antiviral responses in teleost fish.BMC biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Type I interferons (IFNs) are pleiotropic cytokines widely recognized for their roles in the innate immunity of vertebrates, from fish to mammals. Previously, seven type I IFNs were identified in the order of Cypriniformes, the largest group of freshwater fish. Using whole genome analysis, we have identified the IFNf from this order, expanding the number of type I IFNs in this order to eight. IFNf exhibited conserved synteny across 25 Cypriniformes genomes and phylogenetically predated the divergence of group 1 and group 2 type I IFNs. Despite low sequence identity at both the nucleotide and protein levels, IFNf retained a conserved gene structure and three-dimensional conformation essential for its function. Expression analysis revealed drastic upregulation of IFNf in grass carp upon infection with hemorrhagic virus (GCRV-II), with the highest level of activation among all the eight IFNs. Additionally, four chemically synthesized α-helix peptides derived from both grass carp and zebrafish IFNfs acted as antimicrobial peptides (AMPs), displaying direct inhibitory activity against a variety of microorganisms. Thus, this study establishes IFNf as an important component of the immune system in Cypriniformes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.