Evidence map›Paper›PMID 40619439›Full record

Trial reportEuropean journal of medical research2025

Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery.

Neshat Mohammadi, Mehdi Alizadeh, Samad Akbarzadeh, Mikaeeil Rezaei, Marzieh Mahmoodi, Thomas Netticadan, Ali Movahed

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neshat MohammadiDepartment of Clinical Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran.
Mehdi AlizadehDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Samad AkbarzadehDepartment of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
Mikaeeil RezaeiDepartment of Cardiovascular Surgery, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. Mikaealrezaei50@yahoo.com.
Marzieh MahmoodiDepartment of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran.
Thomas NetticadanCanadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, R2H 2A6, Canada.
Ali MovahedDepartment of Clinical Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. amovahed58@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to assess the effect of oral melatonin consumption on improving heart function and reducing postoperative complications in patients undergoing coronary artery bypass grafting (CABG) surgery.

methodsA total of 60 CABG patients in the postoperative period were included in this randomized, double-blind, placebo-controlled trial. The patients were divided into three groups: Group 1 (n = 20, 5 mg melatonin), Group 2 (n = 20, 10 mg melatonin), and the placebo group (n = 20). The patients were discharged about 8 to 10 days after the surgery. Blood samples were taken from all the patients before and after the intervention (for 60 days), and Biochemical parameters including creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), total antioxidant capacity (TAC), nitric oxide (NO) assessed. Echocardiography and the measurement of systolic and diastolic blood pressure were also performed on participants.

resultsOur results showed that melatonin treatment significantly increased the ejection fraction (%EF) and TAC levels in both the treatment groups compared to the placebo group (P < 0.05). Moreover, the levels of inflammatory and oxidative biomarkers, including TNF-α, MDA, and NO, decreased in the intervention group significantly (P < 0.05). In the placebo group, %EF decreased significantly (P = 0.042), while MDA increased (P < 0.001) and TAC decreased (P = 0.002). No significant changes were observed in LDH and CK-MB levels. The comparison of serum biomarkers between the two treatment groups showed that 10 mg of melatonin was more effective than 5 mg, but the difference was not significant (P > 0.05).

conclusionThe present study showed that as a potential antioxidant, melatonin could alleviate oxidative stress and inflammation associated with CABG and is essential in improving overall heart function.

trial registrationIRCT20111119008129N14, first trial registration date: 01/08/2023.

Indexed as

Coronary Artery BypassInflammationMelatoninOxidative StressPostoperative ComplicationsAgedAntioxidantsBiomarkersDouble-Blind MethodFemaleHumansMaleMiddle AgedAntioxidantsBiomarkersMelatoninAntioxidantCABGInflammationMelatoninOxidative stress

Identifiers

PMID40619439
PMCPMC12232798

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.