Evidence map›Paper›PMID 40619554›Full record

ArticleMycopathologia2025

One-Year Patient Survival After COVID-19-Associated Rhino-Orbital-Cerebral Mucormycosis: A Multicenter Study.

Bahram Eshraghi, Behzad Khademi, Mohsen Bahmani Kashkouli, Gholamreza Khataminia, Mohammad Yaser Kiarudi, Reza Nabie, Mahdi Abounoori, Samira Chaibakhsh, Hossein Ghahvehchian, Fereshte Rastegarnasab and 18 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05097664 (Ocular Manifestation and Related Risk Factors of Covid-19 Associated Mucormycosis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05097664 unknown statusnot on this map

Ocular Manifestation and Related Risk Factors of Covid-19 Associated Mucormycosis: a Multicenter Study in Iran

TypeobservationalSponsorIsfahan University of Medical SciencesRan2021 to 2022Enrolled250ConditionsCOVID-19, Mucormycosis
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Bahram EshraghiIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0002-6909-2551
Behzad KhademiPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-9316-309X
Mohsen Bahmani KashkouliDepartment of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA.
Gholamreza KhataminiaInfectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.ORCID http://orcid.org/0000-0002-5169-9179
Mohammad Yaser KiarudiEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0002-0973-1366
Reza NabieNikookari Eye Center, Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0001-6583-3028
Mahdi AbounooriIsfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0003-3033-9737
Samira ChaibakhshEye Research Center, Eye Department, School of Medicine, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran.
Hossein GhahvehchianSkull Base Research Center, Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0001-6498-1408
Fereshte RastegarnasabStudent Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0003-2366-7804
Mohammadmehdi ParandinEye Research Center, Emam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID http://orcid.org/0000-0002-8223-2539
Zahra ZiaPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-8056-5989
Soroush KaramiradInfectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.ORCID http://orcid.org/0000-0002-1345-0639
Soheyla JafarpourSkull Base Research Center, Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-2500-4959
Mostafa FakoorMashhad Eye Research Center, Department of Ophthalmology, Mashhad University of Medical Science, Mashhad, Iran.ORCID http://orcid.org/0000-0001-5473-7217
Mojtaba VarshochiTabriz Infectious and Tropical Diseases Research Center, Department of Infectious Diseases, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0003-3740-5370
Majid MirmohammadkhaniSocial Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Alireza Ramezani-MajdIsfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Masoud JanipourOtolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0003-2626-4955
Atefe Mahdian RadInfectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.ORCID http://orcid.org/0000-0003-0030-7793
Farid ShekarchianEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0003-0587-3719
Vahideh ManouchehriNikookari Eye Hospital, Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0002-1214-7865
S Mohammad Javad SajjadiPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-3049-4692
Mohammad Etezad RazaviEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0001-9148-4300
Hajar KhosropourDepartment of Health Information Technology, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Ali ForouhariIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh EbrahimiSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0001-5878-2744
Mohsen PouraziziIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran. m.pourazizi@yahoo.com.ORCID http://orcid.org/0000-0002-9714-8209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince December 2019, a serious health crisis caused by severe acute respiratory syndrome-Coronavirus-2 affected all aspects of human lives. The available data about COVID-19-associated Rhino-Orbital-Cerebral Mucormycosis (CA-ROCM) survival issues are based on studies on small populations with limited follow-up durations. Therefore, this multicenter cohort of a large population with CA-ROCM is aiming to report the one-year survival rate and investigate the potential responsible risk factors affecting the mortality. MATERIALS AND

methodsThis prospective, longitudinal, multicenter study included CA-ROCM patients from eight tertiary ophthalmology centers across Iran. Demographic, clinical, and therapeutic data were collected and patients were followed for a year. Survival analysis was performed using Cox proportional hazards models to identify mortality-associated risk factors. The research protocol is also available on ClinicalTrials.gov (NCT05097664).

resultsAmong the 246 patients, 183 (74.4%) survived within a year and 63 (25.6%) died. Significant mortality risk factors included need for orbital exenteration (HR = 3.01 vs. other treatments, p = 0.019), advanced disease stage (HR = 2.43 stage IV vs. II, p = 0.02), age (HR = 1.05, p < 0.001), and diabetes duration (HR = 1.05, p = 0.002). Paradoxically, steroid administration for COVID management was associated with improved survival (HR = 2.72 for no steroids, p = 0.018). DISCUSSION: COVID-19-associated Rhino-Orbital-Cerebral Mucormycosis carries a substantial one-year survival rate of 74.4% in Iran. Age, diabetes, advanced disease stage, and need for orbital exenteration are the probable fatal risk factors. Interestingly, administration of steroids for COVID management was associated with a better survival.

Indexed as

Brain DiseasesCOVID-19MucormycosisOrbital DiseasesAdultAgedFemaleHumansIranLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsSARS-CoV-2Survival AnalysisCOVID-19COVID-19-associated mucormycosisDiabetesMortalityMucormycosis

Identifiers

PMID40619554

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.