Evidence map›Paper›PMID 40619619›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β-TrCP-Mediated IFNAR1 Degradation.

Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qianya WanDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.ORCID https://orcid.org/0000-0002-1841-9438
Lin ZhuState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, 999077, China.
Cien ChenDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Li ZhongState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, 999077, China.
Houying LeungDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Wei LiWeihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Shandong, 264200, China.
Chang XuWeihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Shandong, 264200, China.
Xi YaoDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Huan HuDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Mandi WuDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Yuxin HouState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, China.
Hin ChuState Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, China.
Yiran WangDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Sheng ChenDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Mingyu PanDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.
Zongwei CaiState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, 999077, China.
Ming-Liang HeDepartment of Biomedical Sciences and Tung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, 999077, China.

Funding

City University of Hong KongHong Kong Baptist University 162874Hong Kong Scholars Program, The Society of Hong Kong Scholars and China National Postdoctoral Council XJ2022044RGC General Research Fund of Hong Kong Special Administrative Region 11104020Science Technology and Innovation Committee of Shenzhen Municipality JCYJ20180507181627057
6 · The paper itself

Abstract

Virus infection stimulates proto-oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity during human coronavirus HCoV-OC43 infection. During virus replication, the double-stranded viral RNA and some viral proteins upregulate PIM1 expression, which phosphorylates E3 ubiquitin ligase β-TrCP1 at Serine 82. The pS82-β-TrCP1 then forms a complex with S535/S539-phosphorylated interferon receptor IFNAR1 (pS535/539-IFNAR1), leading to IFNAR1 ubiquitination and degradation. Both pan-inhibitors (CX-6528, SGI-1776, AZD-1208) and a specific inhibitor of PIM1 kinase (PIM1 inhibitor 2) effectively block this process and potently inhibit viral replication. This studies demonstrate a novel strategy that viruses use to disrupt cellular innate immunity, suggesting a potential therapeutic target for further anti-virus drug development.

Indexed as

beta-Transducin Repeat-Containing ProteinsImmunity, InnateProto-Oncogene Proteins c-pim-1Receptor, Interferon alpha-betaVirus ReplicationHEK293 CellsHumansProteolysisUbiquitinationbeta-Transducin Repeat-Containing ProteinsIFNAR1 protein, humanPIM1 protein, humanProto-Oncogene Proteins c-pim-1Receptor, Interferon alpha-betaIFNAR1PIM1ubiquitinationβ‐coronavirusβ‐TrCP1

Identifiers

PMID40619619
PMCPMC12499414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.