Evidence map›Paper›PMID 40620323›Full record

ArticleRegenerative biomaterials2025

Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence.

Xin Zhao, Yubo Shi, Zhen Sun, Wei Duan, Le Chang, Benchi Xu, Kangwei Lai, Jingchun Zhang, Buqi Tian, Weidong Tao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin ZhaoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Yubo ShiDepartment of Orthopedic Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang 441000, P. R. China.
Zhen SunDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Wei DuanDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Le ChangDepartment of Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, P. R. China.
Benchi XuDepartment of Orthopaedics, The 986th Air Force Hospital, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P. R. China.
Kangwei LaiDepartment of Orthopaedics, Xi'an Medical University, Xi'an 710021, P. R. China.
Jingchun ZhangDepartment of Orthopaedics, Xi'an Medical University, Xi'an 710021, P. R. China.
Buqi TianDepartment of Orthopaedics, Xi'an Medical University, Xi'an 710021, P. R. China.
Weidong TaoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Zhenzhou MiDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Mian ZhangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Wenjing YangDepartment of Stomatology, The 986th Air Force Hospital, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P. R. China.
Zhuojing LuoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.
Zhengxu YeDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, P. R. China.ORCID https://orcid.org/0009-0006-8426-1858

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration is a significant contributor to the development of spinal disorders. Previous studies have shown that the senescence of nucleus pulposus cells can worsen the degradation of intervertebral disks. Therefore, targeting the senescence of nucleus pulposus cells may be a promising therapeutic approach for the treatment of intervertebral disc degeneration. This study investigated the use of exosomes from hypoxic umbilical cord-derived mesenchymal stem cells to reverse nucleus pulposus cells senescence and delay intervertebral disc degeneration progression. MicroRNA sequencing of hypoxic umbilical cord-derived mesenchymal stem cells revealed the presence of functional microRNAs, with the p53 signalling pathway identified as a key factor. To enhance the release time of hypoxic umbilical cord-derived mesenchymal stem cells

Indexed as

exosomehydrogelintervertebral disc degenerationsenescenceumbilical cord-derived mesenchymal stem cells

Identifiers

PMID40620323
PMCPMC12226454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.