Evidence map›Paper›PMID 40620413›Full record

Articlenpj biomedical innovations2025

A biosynthetic thumb prosthesis.

Sachi Bansal, Gracia V Lai, Marcus Belingheri, Amber Q Kashay, Jinyoung Kim, Alyssa Tomkinson, Samantha Herman, Keval Bollavaram, Brian K Zukotynski, Sean Thomas and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sachi BansalDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA USA.
Gracia V LaiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA USA.
Marcus BelingheriDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA USA.
Amber Q KashayDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA USA.
Jinyoung KimDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA USA.
Alyssa TomkinsonDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA USA.
Samantha HermanDepartment of Physics and Astronomy, University of California Los Angeles, Los Angeles, CA USA.
Keval BollavaramDepartment of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA USA.
Brian K ZukotynskiDepartment of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA USA.
Sean ThomasDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA USA.
Nirbhay S JainDepartment of Plastic Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA USA.
Kodi K AzariDepartment of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA USA.
Lauren E WesselDepartment of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA USA.
Tyler R ClitesDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA USA.

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.6M
Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb SalvageDP2HD111538 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLITES, TYLER R · 2022 to 2025
$2.4M
NIAMS NIH HHS T32 AR059033NICHD NIH HHS DP2 HD111538
6 · The paper itself

Abstract

In cases of severe damage to the extremities, the function and structure of compromised tissues must be replaced. If biological reconstruction using autologous tissue is not feasible, amputation and replacement with a synthetic prosthesis is often the next best option. Synthetic prostheses are limited, especially in their ability to restore skin sensation. Here we show a biosynthetic prosthesis that combines the versatility of titanium with the rich sensory capabilities of biological skin. The prosthesis recreates opposition pinch by linking motion of the prosthetic joint to that of the residual biological joint, and is enclosed in neurotized skin from the patient's own body. We validated the biosynthetic thumb's mechanical function on the benchtop and in a cadaver, and showed viability of the skin interface in an animal model. These results provide a framework for functional reconstruction of amputated digits using a combination of synthetic materials and biological tissues.

Indexed as

Preclinical researchTranslational researchTrauma

Identifiers

PMID40620413
PMCPMC12222026

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.