ArticleSmart medicine2025
Conductive Nerve Conduits With Orientated Topological Structures From Ice-Templating Technology.
Article in Smart medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Balancing topographical guidance and spatial capacity: Optimized spatial density of micropatterned filaments for enhanced peripheral nerve regeneration.Materials today. Bio · 2026Article
- A diameter-adaptive, suture-free conduit with magnetoelectric responsiveness promotes peripheral nerve regeneration.Bioactive materials · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Bioactive hydrogels for the reconstruction of sensorineural hearing loss.Bioactive materials · 2026Review
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Conductive Nerve Guidance Conduits Loaded With Adipose Mesenchymal Stem Cells for Peripheral Nerve Regeneration.Smart medicine · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artificial nerve conduits hold significant promise for treating nerve injuries, with researchers focusing on simplifying techniques to harness microstructures and functions to improve their therapeutic outcomes. Here, a type of conductive nerve guidance conduit (NGC) with orientated topological structures from ice-templating technology is presented for promoting peripheral nerve regeneration. Based on a temperature gradient generated by a thermoelectric cooling platform, conductive carbon nanotubes (CNTs) and methacrylated gelatin are introduced into the ice crystal template to create conductive conduits with unique oriented structures. Ascribed to such structures, together with the great conductivity of CNTs and the loaded nerve growth factors, the obtained conduits can direct the neurite extension and facilitate the differentiation and growth of nerve cells. By constructing rat models with long-segment sciatic nerve defects, it was confirmed that such conductive NGCs can effectively improve injured nerve regeneration and motor function recovery. These features reveal the practical application value and broad prospect of our prepared NGCs in improving peripheral nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.