Evidence map›Paper›PMID 40620597›Full record

ArticleGlobal heart2025

Unraveling the Causal Links Between Immune Cells, Lipids, and Cardiovascular Diseases: Insights from Mendelian Randomization.

Fengwei He, Tian Yang, Wentao Zhang, Ming Liu, Hao Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fengwei HeDepartment of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Tian YangDepartment of Cell Biology and Medical Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China.
Wentao ZhangDepartment of Cell Biology and Medical Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China.
Ming LiuDepartment of Cell Biology and Medical Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0001-9785-6056
Hao WuDepartment of Cell Biology and Medical Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0002-9310-8998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Cardiovascular diseases (CVD), including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and ischemic stroke (IS), are major causes of morbidity and mortality worldwide. Immune cells play crucial roles in CVD, but causal links between immune cell subtypes and CVD risk remain unclear. This study used Mendelian randomization (MR) to investigate these associations. Methods and Results: Exposure data were analyzed with a P < 1 × 10 Conclusions: Our findings highlight immune cell subtypes and lipid traits in CVD risk. Regulatory T cells and protective phenotypes are therapeutic targets, while LDL and triglycerides mediate immune-disease pathways, emphasizing immune-lipid interactions for targeted therapies.

Indexed as

Cardiovascular DiseasesLipidsMendelian Randomization AnalysisHumansPolymorphism, Single NucleotideLipidsCardiovascular DiseasesCausalityImmune CellsLipid ProfilesMediatorMendelian Randomization

Identifiers

PMID40620597
PMCPMC12227087

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.