ReviewCentral-European journal of immunology2025
Innate immunosenescence and sepsis in the elderly: mechanisms and innate immune modulation strategies.
Review in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- An interpretable prediction model for severe sepsis-associated acute kidney injury in older ICU patients with sepsis: a prospective multicenter cohort study.BMC geriatrics · 2026Article
- First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis.BMC infectious diseases · 2026Article
- Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study.Immunity & ageing : I & A · 2026Article
- Therapeutic Strategies and Clinical Outcomes of Infections Following Anterior Cruciate Ligament Reconstruction: A Narrative Review.Orthopaedic surgery · 2026Review
- Mechanistic clues from urinary trypsin inhibitor in sepsis research.Central-European journal of immunology · 2025Article
- Association of vitamin A and D deficiency and the presence of sepsis in the geriatric population: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
This study aimed to investigate the mechanisms of innate immunosenescence in elderly patients with sepsis and to evaluate the potential application of innate immune modulation strategies in clinical management. Through a literature review, the characteristics of sepsis in the elderly, the aging mechanisms of the innate immune system, the impact of immunosenescence on susceptibility to sepsis, and clinical management strategies for sepsis in the elderly were analyzed. The incidence and mortality rates of sepsis in the elderly increase significantly with age, closely related to the severity of infection, the high prevalence of comorbidities, atypical symptoms, and a greater risk of multi-organ failure. Innate immunosenescence, including the decline in function of neutrophils, monocytes/macrophages, natural killer cells, and dendritic cells, is a key factor in the increased susceptibility to sepsis in the elderly. Immunomodulatory treatments, such as granulocyte colony-stimulating factor (G-CSF), interferon
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