Evidence map›Paper›PMID 40622016›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities.

Ping Che, Siqi Wang, Xiaojiao Liu, Yunyao Lu, Zhuo Tian, Qixin Feng, Feifan Chen, Nan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. New perspectives on VEGF signalling in Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2026
    Review
  3. Article
  4. The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Plasma placental growth factor as a susceptibility biomarker for longitudinal cognitive change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ping CheDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Siqi WangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Xiaojiao LiuDepartment of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.
Yunyao LuDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Zhuo TianDepartment of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.
Qixin FengDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Feifan ChenDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Nan ZhangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

Funding

Science and Technology Innovation 2030-Major Projects 2021ZD0201805Science and Technology Innovation 2030-Major Projects 2022ZD0211605Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-004ATianjin Natural Science Foundation 24JCYBJC00650Tianjin Public Health Science and Technology Major Project 24ZXGZSY00060
6 · The paper itself

Abstract

introductionPlacental growth factor (PlGF) was recently shown to be associated with cerebrovascular and neurodegenerative diseases. The changes of PlGF level in patients with subcortical ischemic vascular dementia (SIVD) and its associations with cognitive function remain unclear.

methodsSeventy patients with SIVD, 102 patients with symptomatic Alzheimer's disease, 40 patients with frontotemporal lobar degeneration, and 38 cognitively unimpaired controls (CUCs) were included. The plasma level of PlGF was measured via electrochemiluminescence immunoassay.

resultsThe plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. Mediation analysis revealed that white matter hyperintensities (WMHs) volume mediated the effect of plasma PlGF levels on cognitive functions in a transdiagnostic cohort. DISCUSSION: The plasma PlGF is a potential biomarker for screening and diagnosing SIVD, and its correlation with cognitive function may be partly mediated by the WMHs. HIGHLIGHTS: Plasma placental growth factor (PlGF) showed high diagnostic value for subcortical ischemic vascular dementia. Plasma PlGF showed significantly negative correlation with cognition. White matter hyperintensities mediated the relationship between plasma PlGF and cognition.

Indexed as

CognitionDementia, VascularPlacenta Growth FactorWhite MatterAgedAlzheimer DiseaseBiomarkersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedBiomarkersPGF protein, humanPlacenta Growth FactorAlzheimer's diseasebiomarkercerebral small vessel diseaseplacental growth factorsubcortical ischemic vascular dementiawhite matter hyperintensities

Identifiers

PMID40622016
PMCPMC12441591

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.