ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Food Additives: Emerging Detrimental Roles on Gut Health.
Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Ultra-Processed Foods and Metabolic Dysfunction: Mechanisms, Clinical Implications, and Public Health Perspectives. Position Paper of the Italian Association of Dietetics and Clinical Nutrition (ADI).Current nutrition reports · 2026Review
- Diet, Ultra-Processed Foods, and Food Additives in Crohn's Disease: A Comprehensive Review.Nutrients · 2026Review
- The Hidden Burden of Water-Binding Additives in Meat Products: Biochemical, Clinical, and Psychosocial Implications.Molecular nutrition & food research · 2026Review
- Ultra-Processed Foods, MASLD, and Cognitive Aging: A Processing-Centered Gut-Liver-Brain Axis Perspective.Nutrients · 2026Review
- Microalgae as Future Foods: Unlocking Their Potential and Overcoming Barriers to Market Adoption and Commercialization.Foods (Basel, Switzerland) · 2026Review
- The Purpose of Food Processing and Ultra-Processed Food: the Potential, Pitfalls and Path Forward for Public Health.Current nutrition reports · 2026Review
- Mutual Influence of Sucralose and Bisphenol A on Biological and Neurobehavioral Action inInternational journal of molecular sciences · 2026Article
- Processed Diets and Food Additives Shape the Gut Microbiota and Chronic Disease Risk Across the Life Course-A Three-Layer Ecosystem Disruption Model (TLED) Model.Life (Basel, Switzerland) · 2026Review
- Gut Microbiota and Nutritional Profiles of Colon Cancer Patients Undergoing Chemotherapy: A Longitudinal Pilot Study.Nutrients · 2026Article
- Food preservatives: natural or synthetic?Archives of microbiology · 2026Review
- Dietary exposure to food additives in ultra-processed foods: implications for gut microbiome, metabolic health, and risk assessment.Frontiers in public health · 2026Review
- Therapeutic application of feeding strategies in chronic pancreatitis: the potential for jejunal feeding and elemental diet to modulate pancreatic secretion to alleviate painful symptoms.Frontiers in physiology · 2026Review
- Exposure to calcium stearyl lactylate induces hepatointestinal toxicity and gut microbiota dysbiosis in mice.Current research in toxicology · 2026Article
- Food Preservatives and the Rising Tide of Early-Onset Colorectal Cancer: Mechanisms, Controversies, and Emerging Innovations.Foods (Basel, Switzerland) · 2025Review
- Food Additives: Emerging Detrimental Roles on Gut Health.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Processed and ultra-processed foods have become dietary staples in many developed countries. A major constituent of these foods is a variety of synthetic chemical additives, which are used to improve the texture, preservation, and aesthetics of food. Evidence is mounting that synthetic chemicals used as food additives may have harmful impacts on health. Studies have linked certain additives to health conditions such as attention deficit hyperactivity disorder, cancer, and obesity. In addition, emerging evidence suggests that additives, such as emulsifiers, artificial sweeteners, colorants, and preservatives, may act as potential disruptors of intestinal homeostasis. Indeed, various studies have identified that food additives can impact gut health by modulating gut microbiota and intensifying intestinal inflammation. Considering the lack of known nutritional benefits of these additives and the accumulating evidence on the detrimental effects of these additives on gut health, further experimental, epidemiological, and clinical evaluations are imperative. This will provide significant advances in the prevention and management of gut health, including intestinal inflammation, and in enriching public knowledge on the harmful effects of these additives. In this review, we explore the effects of popular food additives on gut health with a particular focus on intestinal inflammation and examine the broader implications of these impacts on food safety policy and public health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.