Evidence map›Paper›PMID 40622446›Full record

ArticleJournal of cardiovascular translational research2025

Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients.

Xiufang Jiang, Yanling Lei, Yajuan Yin, Fangfang Ma, Gang Liu, Mingqi Zheng

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiufang Jiang *Department of Medical Affaires, the First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang, 050000, Hebei, China.
Yanling Lei *Department of Pediatrics, the Second Hospital of Hebei Medical University, No. 215 Heping Road, Shijiazhuang, 050000, Hebei, China.
Yajuan Yin *Hebei Key Laboratory of Cardiac Injury Repair Mechanism Study, Shijiazhuang, 050000, Hebei, China.
Fangfang MaDepartment of Cardiology, the First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang, 050000, Hebei, China.
Gang LiuHebei Key Laboratory of Cardiac Injury Repair Mechanism Study, Shijiazhuang, 050000, Hebei, China. cardio2004@hebmu.edu.cn.ORCID 0000-0002-7243-0363
Mingqi ZhengDepartment of Medical Affaires, the First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang, 050000, Hebei, China. mzheng@hebmu.edu.cn.

Funding

Hebei Province Finance Department Project LS202201Key Science and Technology Research Program of Hebei Provincial Health Commission 20201166Key Science and Technology Research Program of Hebei Provincial Health Commission 20210065Key Science and Technology Research Program of Hebei Provincial Health Commission 20230991
6 · The paper itself

Abstract

This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferroptosis, with the severity of coronary artery stenosis and the occurrence of in-stent restenosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients. The study encompassed 396 eligible CAD patients who underwent PCI, followed up for one year. A control group of 100 individuals was selected, matching the baseline data of CAD patients. Compared to healthy controls (HC), CAD patients showed a significant decrease in serum Gpx4 levels and an increase in ferritin levels. Significant disparities were observed in low-density lipoprotein cholesterol, Gensini score, serum Gpx4, and ferritin between the restenosis and no-restenosis groups (p < 0.001). Serum levels of ferritin and Gpx4, markers associated with ferroptosis, correlate with the severity of coronary artery stenosis in CAD patients and the occurrence of in-stent restenosis after PCI.

Indexed as

Coronary Artery DiseaseCoronary RestenosisCoronary StenosisFerroptosisPercutaneous Coronary InterventionPhospholipid Hydroperoxide Glutathione PeroxidaseStentsAgedBiomarkersCase-Control StudiesFemaleFerritinsHumansMaleMiddle AgedPredictive Value of TestsBiomarkersFerritinsPhospholipid Hydroperoxide Glutathione PeroxidaseCoronary heart diseaseFerroptosisIn-Stent restenosisPercutaneous coronary interventionSerum ferritin

Identifiers

PMID40622446

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.