ArticleAmerican journal of physiology. Heart and circulatory physiology2025
The angiotensin II type 2 receptor attenuates aging-associated arterial stiffness in female mice.
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Arterial stiffness is associated with overall and cardiovascular-specific mortality, and this association is exacerbated in women over 55 yr of age. Recent literature supports that stimulation of the angiotensin II type 2 receptor (AT2R) can protect from arterial stiffening, and that AT2R has a greater role in female cardiovascular physiology relative to males. The current study aimed to investigate the role of the AT2R in sex differences in aging-associated arterial stiffness. In female mice, the aging-related increase in arterial stiffness is temporally associated with a loss of aortic AT2R mRNA expression, but this is not observed in males. Chronic AT2R inhibition in vivo increases arterial stiffening in young female and male mice, as well as middle-aged female mice. The inhibition of AT2R is associated with an increase in aortic integrinα5 mRNA expression in young males and an increase in collagen1α1 mRNA expression in middle-aged females. Overall, these findings identify a sex-specific mechanism of aging-associated arterial stiffening in mice involving AT2R attenuation and collagen upregulation in females.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.