Observational studyBMJ open2025
Association of triglyceride-glucose index with in-hospital outcomes in patients with acute myocardial infarction: a retrospective, single-centre, cohort study in China.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
objectivesTo investigate the association between triglyceride-glucose (TyG) index levels at hospital admission and the risk of in-hospital adverse events, including all-cause mortality, in patients with acute myocardial infarction (AMI). The primary hypothesis was that higher TyG index levels are associated with greater risk of adverse in-hospital outcomes.
designRetrospective cohort study.
settingTertiary hospital inpatient care in China. The study included consecutively hospitalised patients with AMI between 1 August 2011 and 10 January 2022.
participantsA total of 3458 patients with AMI were included. The mean age was 60.8 years, and 78.4% were men. Patients were excluded if they had incomplete data for TyG index calculation or outcome ascertainment.
interventionsNo therapeutic intervention was assigned; the study was observational. TyG index was calculated using fasting triglycerides and fasting plasma glucose levels at admission. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was all-cause in-hospital mortality. Secondary outcomes included cardiogenic shock and fatal rapid arrhythmia. Outcomes were identified through standardised clinical records.
resultsAmong 3458 patients, 375 (10.84%) died during hospitalisation, 236 (6.84%) developed cardiogenic shock and 147 (4.25%) experienced fatal rapid arrhythmia. After multivariable adjustment, higher TyG index levels were significantly associated with increased odds of all-cause mortality (OR, 1.27; 95% CI, 1.02 to 1.57; p<0.05) and cardiogenic shock (OR, 1.54; 95% CI, 1.22 to 1.94; p<0.001). When categorised into quartiles, patients in the highest quartile (Q4) had greater odds of mortality (OR, 1.71; 95% CI, 1.10 to 2.65; p<0.05) and cardiogenic shock (Q2: OR, 2.18; 95% CI, 1.39 to 3.45; Q3: OR, 1.71; 95% CI, 1.06 to 2.77; Q4: OR, 2.81; 95% CI, 1.70 to 4.67; all p<0.05 vs Q1). Restricted cubic spline analysis confirmed a linear association between the TyG index and both primary and secondary outcomes.
conclusionHigher TyG index levels at admission are independently associated with an increased risk of all-cause mortality and cardiogenic shock among patients hospitalised for AMI. These findings suggest that the TyG index may serve as a useful prognostic biomarker for risk stratification in this population. Further prospective studies are warranted to validate its clinical utility.
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