Evidence map›Paper›PMID 40624086›Full record

ArticleScientific reports2025

Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography.

Kosei Yanagida, Masahiro Miura, Hidetaka Noma, Toshihiro Mino, Shinnosuke Azuma, Thitiya Seesan, Shuichi Makita, Yoshiaki Yasuno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kosei YanagidaDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Inashiki, Ami, 300395, Ibaraki, Japan. kyanagida719@gmail.com.
Masahiro MiuraDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Inashiki, Ami, 300395, Ibaraki, Japan.
Hidetaka NomaDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Inashiki, Ami, 300395, Ibaraki, Japan.
Toshihiro MinoTopcon Corporation, Tokyo, Japan.
Shinnosuke AzumaTopcon Corporation, Tokyo, Japan.
Thitiya SeesanComputational Optics Group, University of Tsukuba, Tsukuba, Japan.
Shuichi MakitaDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Inashiki, Ami, 300395, Ibaraki, Japan.
Yoshiaki YasunoDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Inashiki, Ami, 300395, Ibaraki, Japan.

Funding

Japan Science and Technology Agency JPMJCR2105Japan Science and Technology Agency JPMJMI18G8Japan Society for the Promotion of Science 21H01836Japan Society for the Promotion of Science 21K09684Japan Society for the Promotion of Science 24K12753
6 · The paper itself

Abstract

Retinal pigment epithelium (RPE) melanin thickness maps, derived from multi-contrast images-including the degree of polarization uniformity (DOPU), optical coherence tomography (OCT) angiography, and the attenuation coefficient-are obtained using multi-contrast polarization-sensitive OCT (PS-OCT). These maps have demonstrated utility for three-dimensional assessment of changes in melanin within the RPE (RPE-melanin). While both OCT angiography and the attenuation coefficient can be derived from conventional OCT, measuring the DOPU requires PS-OCT, which is not available on standard commercial OCT systems. To overcome this limitation, we utilized a convolutional neural network to generate DOPU-like images from standard OCT images and used these to calculate a synthesized RPE-melanin thickness map. We evaluated 22 eyes from 20 patients with serous pigment epithelial detachment (PED) secondary to age-related macular degeneration. Both original and synthesized RPE-melanin thickness maps were calculated from multi-contrast PS-OCT datasets. Active RPE lesions were defined as areas with RPE-melanin thickness of ≥ 70 μm (originalRPE

Indexed as

Retinal DetachmentRetinal Pigment EpitheliumTomography, Optical CoherenceAgedAged, 80 and overFemaleHumansMacular DegenerationMaleMelaninsMiddle AgedMelaninsAge-related macular degenerationConvolutional neural networkMelaninPigment epithelial detachmentPolarization-sensitive optical coherence tomographyRetinal pigment epithelium

Identifiers

PMID40624086
PMCPMC12234684

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.