Evidence map›Paper›PMID 40624113›Full record

ArticleScientific reports2025

GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation.

Yun He, Qin Ni, Cuiyun Zhang, Liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun He *Department of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China. 13615175810@yzu.edu.cn.
Qin Ni *Department of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China.
Cuiyun Zhang *Department of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China.
Liulin ZhouDepartment of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China.
Shuang LiDepartment of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China.
Yu TaoDepartment of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China.
Lanhua LiuDepartment of Obstetrics and Gynecology, Taixing Clinical College of Xuzhou Medical University, Changzheng Road, TaiXing, 225400, China. 13812492159@163.com.

Funding

Taixing People's Hospital doctoral foundation trybs2022002The Maternal and Child Health Research Project of Jiangsu Province F202203The Research project of Jiangsu Association for Science and Technology JSKXKT2023034
6 · The paper itself

Abstract

Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development. This study aimed to investigate the effects of GDM on human umbilical vein (HUV) constriction and the underlying mechanisms. HUVs were collected from pregnancies with gestational diabetes mellitus (GDM) and healthy normal pregnancies (CON). HUVs were isolated and cut into 4-5 mm lengths, then suspended in 5 mL organ baths. Acetylcholine (ACh, 10

Indexed as

AcetylcholineCalcium Channels, L-TypeDiabetes, GestationalDNA MethylationPromoter Regions, GeneticReceptor, Muscarinic M3Umbilical VeinsVasoconstriction3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAdultFemaleHumansPregnancyUp-Regulation3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAcetylcholineCACNA1C protein, humanCalcium Channels, L-TypeReceptor, Muscarinic M3AcetylcholineCACNA1CCHRM3Gestational diabetes mellitusHuman umbilical vein

Identifiers

PMID40624113
PMCPMC12234974

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.