Evidence map›Paper›PMID 40624457›Full record

ReviewCellular & molecular biology letters2025

AKT and DUBs: a bidirectional relationship.

Valentina Serratore, Maria Lucibello, Donatella Malanga, Giuseppe Viglietto, Carmela De Marco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina SerratoreMolecular Oncology Laboratory, Department of Experimental and Clinical Medicine, "Magna Graecia" University, 88100, Catanzaro, Italy.
Maria LucibelloDepartment of Biomedical Sciences, Institute for Biomedical Research and Innovation, National Research Council of Italy (CNR), 88100, Catanzaro, Italy.
Donatella MalangaMolecular Oncology Laboratory, Department of Experimental and Clinical Medicine, "Magna Graecia" University, 88100, Catanzaro, Italy.
Giuseppe VigliettoMolecular Oncology Laboratory, Department of Experimental and Clinical Medicine, "Magna Graecia" University, 88100, Catanzaro, Italy.
Carmela De MarcoMolecular Oncology Laboratory, Department of Experimental and Clinical Medicine, "Magna Graecia" University, 88100, Catanzaro, Italy. cdemarco@unicz.it.ORCID http://orcid.org/0000-0002-4893-4246

Funding

Ministero dell'Università e della Ricerca 2022ELYS5F
6 · The paper itself

Abstract

The serine/threonine kinase Akt is crucial for cell physiology and can also contribute to pathology if its activation and regulation is disturbed. This kinase phosphorylates several substrates involved in mechanisms that are altered in human disease. AKT is regulated by several post-translational modifications (PTMs), including ubiquitination/deubiquitination. Ubiquitination can both target AKT to the proteasome and promote its activation. The interplay with the deubiquitination mechanism plays a crucial role in almost all biological activities of AKT. Information on the mechanisms of AKT deubiquitination and its key players has evolved rapidly in recent years along with the development of potential targeting strategies, although many of them are still unclear. Nevertheless, AKT in turn regulates various deubiquitinases (DUBs), suggesting further targeting strategies for human diseases. In this review, we aim to provide an up-to-date overview of the dual relationship between AKT and DUBs with respect to potential translational aim.

Indexed as

Deubiquitinating EnzymesProto-Oncogene Proteins c-aktAnimalsHumansProtein Processing, Post-TranslationalSignal TransductionUbiquitinationDeubiquitinating EnzymesProto-Oncogene Proteins c-aktAKT kinaseDeubiquitinasesPhosphorylationPost-translational modifications

Identifiers

PMID40624457
PMCPMC12232702

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.