ArticlePhysiological reports2025
Cardiac workload and skeletal muscle oxygenation during incremental exercise in healthy subjects.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Distinguishing Muscle Oxygen Saturation from Tissue Oxygen Saturation: Accuracy, Limitations, and Practical Utility in Muscle Oximetry.Sports medicine - open · 2026Article
- Cardiac workload and skeletal muscle oxygenation during incremental exercise in healthy subjects.Physiological reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We hypothesized that skeletal muscle oxygenation, measured by Near-infrared spectroscopy (mNIRS), is associated with cardiac workload during incremental exercise. Healthy subjects (n = 30, age 27 ± 6, 15 females) performed a maximal exercise test starting from 0 W, following an incremental protocol starting from 40 W and increasing load every 2 min until exhaustion. Systolic blood pressure and breath-by-breath gas exchanges were measured to analyze oxygen uptake and respiratory compensatory point (RCP). Tissue saturation index (TSI) by mNIRS was measured from vastus lateralis. The slopes of TSI and rate pressure product (RPP) were calculated using the values from 0 W to 100% of the RCP threshold. RPP was 31,734 ± 3909 mmHg·bpm, and TSI was 50.0% ± 8.4% at the intensity of RCP. RPP and TSI slopes were 3463 ± 541 and -2.75 ± 1.68, respectively. In linear regression analysis, RPP slope was used as a dependent variable, and sex, body fat %, maximal oxygen uptake, hemoglobin, baseline SBP, and TSI% slope were used as predictor variables; TSI slope was the only variable associated with RPP slope (r = 0.60, p = 0.001). Cardiac workload during submaximal exercise, documented by RPP slope calculated over equal metabolic exercise intensities for all subjects, is partly regulated by skeletal muscle oxygenation, potentially due to the differences in microcirculation and/or mitochondrial properties in healthy young subjects.
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Registered trials
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