Evidence map›Paper›PMID 40625198›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2025

Fn14-Targeted Gold Nanorods for Augmenting Laser Thermal Therapy for High-Grade Gliomas.

Sumiao Pang, Rebecca J Johnson, Nikhil Pandey, Anshika Kapur, Pavlos Anastasiadis, Pranjali Kanvinde, Emylee McFarland, Jeffrey A Winkles, Graeme F Woodworth, Anthony J Kim and 1 more

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sumiao PangFischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland 20742, United States.ORCID 0009-0005-2382-789X
Rebecca J JohnsonFischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland 20742, United States.
Nikhil PandeyDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Anshika KapurDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Pavlos AnastasiadisDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Pranjali KanvindeDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Emylee McFarlandDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Jeffrey A WinklesDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Graeme F WoodworthFischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland 20742, United States.
Anthony J KimFischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland 20742, United States.ORCID 0000-0002-8385-417X
Huang Chiao HuangFischell Department of Bioengineering, University of Maryland at College Park, College Park, Maryland 20742, United States.ORCID 0000-0002-5406-0733

Funding

NIH Director's Pioneer Award (RMI)DP1OD000379 · OD · ROCKEFELLER UNIVERSITY · PI DE LANGE, TITIA · 2005 to 2009
$4.1M
Nanotherapeutic enhancement of interstitial thermal therapy for glioblastomaR01CA269995 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Huang Chiao Huang, Anthony J. Kim · 2023 to 2026
$2.5M
Nanotherapeutic treatment of the invasive glioblastoma microenvironmentR01NS107813 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI WOODWORTH, GRAEME F · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA269995NIH HHS DP1 OD000379NINDS NIH HHS R01 NS107813
6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly aggressive and invasive brain tumor. Tumor recurrence after standard surgery, chemotherapy, and radiation is nearly universal. Unfortunately, only around 25% of GBM patients undergo repeat surgery. Laser interstitial thermal therapy (LITT) is a promising strategy to treat patients with inoperable or recurrent GBM. While advances in magnetic resonance thermometry and laser probe cooling systems have provided significant safety improvements, the full potential of laser thermal therapy is still hindered by the lack of selective targeting of GBM cells. Gold nanorods (GNR) are attractive plasmonic antennas that can efficiently convert laser energy to localized heat for hyperthermal therapy and can be used as contrast agents for computed tomography (CT) imaging. Here, we surface-functionalized GNR with antifibroblast growth factor-inducible 14 (Fn14) antibody and polyethylene glycol to achieve GBM selectivity with low adhesivity to extracellular matrix. Red light activation (690 nm, 2.5 W/cm

Indexed as

Brain NeoplasmsGliomaGoldLaser TherapyNanotubesCell Line, TumorHumansGold

Identifiers

PMID40625198
PMCPMC12732764

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.