ArticleFrontiers in cardiovascular medicine2025
The impact of clopidogrel combined with aspirin or aspirin alone on prognosis and adverse events in patients undergoing coronary artery bypass grafting in the first month after surgery.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Coronary artery bypass grafting (CABG) was a critical intervention for patients with obstructive coronary artery disease, yet managing thrombotic complications post-surgery remains challenging. Aspirin was the standard antiplatelet therapy following CABG; however, the potential benefits of dual antiplatelet therapy (DAPT) with clopidogrel were not well-defined in this setting. This study evaluates the impact of DAPT compared to aspirin alone on prognosis and adverse events in the first month after CABG. Methods: This retrospective cohort study analyzed data from 281 patients undergoing CABG from August 2020 to July 2023. Using propensity score matching (PSM), these patients were separated into two groups based on their postoperative medication: the aspirin alone group (ASA, Results: DAPT resulted in significantly lower rates of saphenous vein graft occlusion compared to aspirin alone (17.09% vs. 29.06%, Conclusion: DAPT with clopidogrel and aspirin improves graft patency and platelet inhibition in the first month following CABG, though it was associated with increased minor bleeding events.
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