ArticleFrontiers in immunology2025
Short-term heavy drinking in a non-human primate model skews monocytes toward a hypo-inflammatory phenotype.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Short-Term Alcohol Consumption Is Sufficient to Disrupt Microbial Communities and the Intestinal and Circulating Metabolites in a Non-Human Primate Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Introduction: Alcohol use is prevalent in the United States (US), with ~80% of persons over 12 years old reporting alcohol consumption in 2023 and ~10% of those individuals developing alcohol use disorder (AUD). Acute and chronic alcohol consumption exert opposite effects on the immune system. Specifically, acute alcohol exposure (AAE), (3-16 hours of Methods: To bridge this gap, we obtained peripheral blood mononucleated cells (PBMC) isolated from rhesus macaques before and after 6 months of daily ethanol consumption (>55% of intakes over 2.0 g/kg/day). Monocytes were analyzed using a combination of flow cytometry, single-cell RNA-sequencing (scRNAseq), ELISAs, and Cleavage Under Targets and Tagmentation (CUT&Tag). Results: Our data show that 6 months of ethanol consumption rewires monocytes towards a hypo-inflammatory profile as evidenced by reduced cytokine production. scRNAseq analysis revealed distinct shifts in monocyte states/clusters with ethanol consumption and LPS stimulation in line with a shift to a hypo-inflammatory state. These changes may be driven by reduced levels of H3k4me3, a histone modification shown to be deposited at promoter regions of genes involved in inflammation and pathogen response signaling. Discussion: Overall, these data demonstrate that 6 months of daily heavy drinking attenuates inflammatory responses in monocytes via shifts in the epigenetic landscape.
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Registered trials
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