Evidence map›Paper›PMID 40625905›Full record

ArticleFrontiers in neurology2025

Overall leukocyte levels link risk factors to Von Willebrand factor and Neutrophil Extracellular Traps in stroke thrombi: a Structural Equation Modeling analysis.

Lin Shi, Chunxiao Wei, Guowei Ye, Panpan Zhao, Shiqiang Ma, Yiming Qi, Ruolin Zhou, Yaru Zhang, Yan Zhang, Lingjie Meng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lin ShiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Chunxiao WeiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Guowei YeDepartment of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.
Panpan ZhaoDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Shiqiang MaDepartment of Neurosurgery Center, The First Hospital of Jilin University, Changchun, China.
Yiming QiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Ruolin ZhouDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Yaru ZhangDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Yan ZhangDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Lingjie MengDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Weihang XuSchool of Public Health, Jilin University, Changchun, China.
Chao LiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Shouchun WangDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Li SunDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Von Willebrand Factor (VWF) and Neutrophil Extracellular Traps (NETs) are involved in the inflammatory response during thrombi formation and are widely found in thrombi of Acute Ischemic Stroke (AIS) patients. Inflammation may mediate the relationship between cerebrovascular risk factors (such as blood glucose) and thrombi components. This study uses overall leukocyte levels to identify potential links between risk factors and VWF, NETs in thrombi. Methods: Thrombi samples and clinical data from 61 stroke patients treated at our hospital between 2017 and 2023 were collected. The Partial Least Squares Structural Equation Modeling (PLS-SEM) assessed direct and indirect associations, with leukocyte and its subtype counts as mediating variables, VWF and NETs as endogenous variables, and cerebrovascular risk factors as exogenous variables. Results: Heart dysfunction and blood glucose showed a significant negative indirect effect on VWF through the overall leukocyte levels (indirect effect = -0.119 and -0.118, Conclusion: Overall leukocyte levels mediate the influence of blood glucose levels, heart dysfunction, and vitamin B12 on content VWF in thrombi in stroke patients. VWF reduction correlates with elevated discharge NIHSS scores. These cerebrovascular factors may regulate the pathological process of AIS thrombosis through inflammatory responses, guiding further exploration of the underlying mechanisms and informing clinical strategies.

Indexed as

Neutrophil Extracellular Traps (NETs)overall leukocyte levelsPartial Least Squares Structural Equation Modeling (PLS-SEM)strokeVon Willebrand factor (VWF)

Identifiers

PMID40625905
PMCPMC12229865

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.