SynthesisFrontiers in nutrition2025
The beneficial effects of probiotics on patients with coronary heart disease: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The oral and lower airway microbiota and coronary heart disease in COPD patients and controls.PloS one · 2026Article
- Effects of probiotics on blood lipids, glucose and pressure in patients with coronary heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Review
- Effects of bifid triple viable capsules dissolving at intestines combined with emergency comprehensive nursing on intestinal microorganism and nutritional status of patients with coronary heart disease after percutaneous coronary intervention.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Coronary heart disease (CHD) is a major global health burden, and emerging evidence suggested that probiotics could improve cardiovascular health by modulating gut microbiota and lipid profiles. However, the efficacy of probiotics remains elusive, indicating the necessity of conducting this meta-analysis. Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, EMBASE, and Web of Science databases for retrieving randomized controlled trials (RCTs) on probiotics' effects on lipid profiles (low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG)) in CHD patients. Inclusion and exclusion criteria concentrated on English-language RCTs, and data on study characteristics were extracted. Study quality was assessed using Cochrane and NHLBI tools, and statistical analysis was conducted via R 4.3.2 software. Results: The literature search identified 263 records, yielding 6 RCTs, 5 of which were included in the meta-analyses. For LDL level ( Conclusion: Probiotics, particularly monotherapy for LDL and combination therapy for HDL, exhibited potential to improve lipid profiles in CHD patients. However, further research is needed to address existing limitations and confirm efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.