Evidence map›Paper›PMID 40626580›Full record

ArticleeLife2025

Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi.

Hieng Chiong Tie, Haiyun Wang, Divyanshu Mahajan, Hilbert Yuen In Lam, Xiuping Sun, Bing Chen, Yuguang Mu, Lei Lu

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hieng Chiong Tie *School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2738-8685
Haiyun Wang *School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID https://orcid.org/0009-0003-5963-2029
Divyanshu MahajanSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID https://orcid.org/0000-0001-5820-6763
Hilbert Yuen In LamSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID https://orcid.org/0000-0001-6129-2703
Xiuping SunSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Bing ChenSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Yuguang MuSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Lei LuSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID https://orcid.org/0000-0002-8192-1471

Funding

Ministry of Education - Singapore Tier 1 RG 25/22Ministry of Education - Singapore Tier 2 MOE-T2EP30221-0001
6 · The paper itself

Abstract

How the intra-Golgi secretory transport works remains a mystery. The cisternal progression and the stable compartment models have been proposed and are under debate. Classic cisternal progression model posits that both the intra-Golgi transport and Golgi exit of secretory cargos should occur at a constant velocity dictated by the cisternal progression; furthermore, COPI-mediated intra-Golgi retrograde transport is essential for maintaining the Golgi organization. Leveraging our recently developed Golgi imaging tools in nocodazole-induced Golgi ministacks, we found that the intra-Golgi transport velocity of a secretory cargo decreases during their transition from the

Indexed as

Golgi ApparatusBiological TransportBrefeldin AHeLa CellsHumansNocodazoleProtein TransportBrefeldin ANocodazolecell biologycisternal progression modelGolgihumanintra-Golgi transportmembrane traffickingstable compartment model

Identifiers

PMID40626580
PMCPMC12237403

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.