Evidence map›Paper›PMID 40627082›Full record

ArticleJournal of endocrinological investigation2025

Association of serum chitinase-3-like protein 1 with sarcopenia in patients with type 2 diabetes mellitus.

Fan Zhang, Yan Han, Yonghua Mao, Liming Zheng, Wenjian Li

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan ZhangDepartment of Endocrinology, Changzhou Third People's Hospital, Changzhou, 213001, China.
Yan HanDepartment of Endocrinology, Changzhou Third People's Hospital, Changzhou, 213001, China.
Yonghua MaoDepartment of Endocrinology, Changzhou Third People's Hospital, Changzhou, 213001, China.
Liming ZhengClinical Laboratory, Changzhou Third People's Hospital, Changzhou, 213001, China.
Wenjian LiDepartment of Urology, Changzhou Third People's Hospital, Changzhou, 213001, China. 760020240117@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-7650-8842

Funding

Changzhou Third Peopls's Hospital Key Talents ProjectNatural Science Foundation of Changzhou Municipality CJ20243023
6 · The paper itself

Abstract

objectiveThis study examined the potential correlation between chitinase-3-like protein-1 (CHI3L1) and sarcopenia in patients with type 2 diabetes mellitus (T2DM). The findings aim to establish a preliminary foundation and valuable reference information for future studies in this area.

methods239 patients with T2DM were enrolled and categorized into groups based on their serum CHI3L1 tertiles. The study compared the incidence of sarcopenia in each group and systematically identified independent risk factors for sarcopenia using multivariate logistic regression analysis. A model was constructed to assess the relative risk of CHI3L1 for sarcopenia in patients with T2DM, and the predictive efficacy of CHI3L1 was analyzed using receiver operating characteristic (ROC) and calibration curves.

resultsThe results showed that the prevalence of sarcopenia in patients with T2DM was 13.81%. The study confidently found a significant correlation between higher serum CHI3L1 levels and increased prevalence of sarcopenia in patients with T2DM. Through multivariate logistic regression analysis, CHI3L1 was independently associated with the presence of sarcopenia in patients with T2DM. Additionally, ROC curve analysis demonstrated that CHI3L1 had good predictive efficacy for sarcopenia with an area under the ROC curve of 0.795 [0.707, 0.883].

conclusionIn patients with T2DM, higher serum levels of CHI3L1 were significantly associated with an increased prevalence of sarcopenia.

Indexed as

BiomarkersChitinase-3-Like Protein 1Diabetes Mellitus, Type 2SarcopeniaAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrevalencePrognosisRisk FactorsROC CurveBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1Chitinase-3-like protein 1InflammationInsulin resistanceSarcopeniaType 2 diabetes mellitus

Identifiers

PMID40627082

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.