SynthesisHormones (Athens, Greece)2025
Epidemiological characteristics and risk factors of reproductive dysfunction in male infertility: a meta-analysis.
Synthesis in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Assessment of Associations Between Demographic Characteristics, Lifestyle Factors, and Sperm Quality Among Men Presenting With Infertility Complaints.Health science reports · 2026Article
- Nutritional modulation of male fertility: a molecular-focused scoping review.Journal of health, population, and nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReproductive dysfunction, encompassing semen abnormalities and sexual dysfunction, is a significant global concern with diverse etiological factors. This meta-analysis investigated the demographic, lifestyle, and health-related risk factors that contribute to reproductive dysfunction in men.
methodsA comprehensive search of electronic databases yielded 3,931 publications, of which 28 articles (44 studies) involving 23,316 infertile men and 40,934 healthy controls were included. Data extraction and analysis followed the PRISMA guidelines. Risk factors were assessed using standardized mean difference (SMD) and odds ratio (OR) metrics, with stratified and subgroup analyses based on the population and condition.
resultsAdvanced age was identified as a significant risk factor for reproductive dysfunction (SMD = 1.15, 95% CI [0.68, 1.61], P < 0.001, I
conclusionsThis meta-analysis highlights advanced age, elevated BMI, smoking, alcohol consumption, hypertension, diabetes, and mental health disorders as critical risk factors for male reproductive dysfunction. These findings underscore the importance of targeted interventions and lifestyle modifications in mitigating these risks. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
40627328What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.