Evidence map›Paper›PMID 40627341›Full record

ArticleACS applied materials & interfaces2025

Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.

Wenwu Zhu, Yao Lu, Bin Zong, Ziyi Chen, Yong Ma, Haoran Wang, Peng Cao, Bing Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenwu ZhuXuzhou Clinical School of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou 221000, China.
Yao LuXuzhou Clinical School of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou 221000, China.
Bin ZongXuzhou Clinical School of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou 221000, China.
Ziyi ChenState Key Laboratory ofTechnologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yong MaThe Second AffiliatedHospital of Xuzhou Medical University, Xuzhou 221000, China.
Haoran WangState Key Laboratory ofTechnologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0002-1630-4813
Peng CaoState Key Laboratory ofTechnologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0002-2044-3074
Bing HanXuzhou Clinical School of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou 221000, China.ORCID 0009-0009-1247-9235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ideal treatment for myocardial infarction should address the critical issues of oxygen supply improvement in the infarcted area and prevention of myocardial cell death. Myocardial necrosis is a reversible process, but the challenge lies in mitigating the irreversible pyroptosis of cardiomyocytes, which significantly impedes the recovery of cardiac function. To tackle these complexities, here we have developed MnO

Indexed as

Drug CarriersGlyburideMyocardial InfarctionNanoparticlesOxygenPyroptosisAnimalsManganese CompoundsMiceMyocytes, CardiacNLR Family, Pyrin Domain-Containing 3 ProteinOxidesDrug CarriersGlyburideManganese Compoundsmanganese dioxideNLR Family, Pyrin Domain-Containing 3 ProteinOxidesOxygenBiocompatibilityEndogenous oxygen transportFibrosis reversalMyocardial infarctionPyroptosis inhibiting

Identifiers

PMID40627341
PMCPMC12291080

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.