ArticleEnvironment international2025
Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.
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Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pollutant Burden in Autism Spectrum Disorder: Mechanistic Convergence, Genetic Susceptibility, and Clinical Translation.Current issues in molecular biology · 2026Review
- Joint associations between gestational environmental chemical mixtures and child behavioral outcomes.Environment international · 2026Article
- Association between maternal organophosphate esters metabolite levels during pregnancy and internalizing and externalizing behaviors in children at 2-5 years.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Characterizing Prenatal Exposure to Contemporary and Emerging Chemicals in a Prospective Cohort of Pregnant Women in Atlanta, Georgia.Environment & health (Washington, D.C.) · 2026Article
- Prenatal exposure to organophosphate ester flame retardants and child cognition: Findings from the environmental influences on child Health Outcomes cohort.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Associations between brominated and organophosphate flame retardant levels and inflammatory biomarkers in maternal blood, cord blood, and placental tissue at mid-gestation.The Science of the total environment · 2025Article
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Authors and funding
32 authors.
Jiwon OhDepartment of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA. Electronic address: jiwoh@ucdavis.edu.
Lesliam Quirós-AlcaláDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. Electronic address: lalcala1@jhu.edu.
Xuan LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA. Electronic address: xli332@jh.edu.
Kurunthachalam KannanDivision of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12237, USA; Department of Environmental Health Sciences, University at Albany, State University of New York, 1400 Washington Ave, Albany, NY 12222, USA. Electronic address: kurunthachalam.kannan@health.ny.gov.
Wenjie LyuDepartment of Pediatrics, New York University Grossman School of Medicine, 550 1st Ave., New York, NY 10016, USA; Department of Environmental Medicine, New York University Grossman School of Medicine, 550 1st Ave., New York, NY 10016, USA. Electronic address: wenjie.lyu@nyulangone.org.
Lyndsay A AvalosDivision of Research, Kaiser Permanente Northern California, 1 Kaiser Plaza, Oakland, CA 94612, USA. Electronic address: Lyndsay.A.Avalos@kp.org.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, 683 Hoes Ln W, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, the State University of New Jersey, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA. Electronic address: esb104@eohsi.rutgers.edu.
Theresa M BastainDepartment of Population and Public Health Sciences, University of Southern California, 1845 N Soto St, Los Angeles, CA 90032, USA. Electronic address: bastain@usc.edu.
Jessie P BuckleyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC 27599, USA. Electronic address: Jessie.Buckley@unc.edu.
Patricia CintoraBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA. Electronic address: cintora2@illinois.edu.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, 1 Kaiser Plaza, Oakland, CA 94612, USA. Electronic address: Lisa.A.Croen@kp.org.
Anne L DunlopDepartment of Gynecology and Obstetrics, Emory University School of Medicine, 1518 Clifton Rd N E, Atlanta, GA 30322, USA. Electronic address: amlang@emory.edu.
Akhgar GhassabianDepartment of Pediatrics, New York University Grossman School of Medicine, 550 1st Ave., New York, NY 10016, USA; Department of Population Health, New York University Grossman School of Medicine, 550 1st Ave., New York, NY 10016, USA. Electronic address: Akhgar.Ghassabian@nyulangone.org.
Rima HabreDepartment of Population and Public Health Sciences, University of Southern California, 1845 N Soto St, Los Angeles, CA 90032, USA. Electronic address: habre@usc.edu.
Julie B HerbstmanDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 W 168th St, New York, NY 10032, USA. Electronic address: jh2678@cumc.columbia.edu.
Ixel Hernandez-CastroDepartment of Population and Public Health Sciences, University of Southern California, 1845 N Soto St, Los Angeles, CA 90032, USA. Electronic address: ixelhern@usc.edu.
Irva Hertz-PicciottoDepartment of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA; UC Davis MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, 2825 50th St, Sacramento, CA 95817, USA. Electronic address: iher@ucdavis.edu.
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA. Electronic address: donghai.liang@emory.edu.
Cindy T McEvoyDepartment of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA. Electronic address: mcevoyc@ohsu.edu.
Thomas G O'ConnorDepartment of Psychiatry, University of Rochester, 500 Joseph C. Wilson Blvd. Rochester, NY 14627, USA. Electronic address: tom_oconnor@urmc.Rochester.edu.
Sheela SathyanarayanaDepartment of Pediatrics, University of Washington and Seattle Children's Research Institute, 4800 Sand Point Way NE Seattle, WA 98105, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.org.
Susan L SchantzBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA. Electronic address: schantz@illinois.edu.
Rebecca J SchmidtDepartment of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA; UC Davis MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, 2825 50th St, Sacramento, CA 95817, USA. Electronic address: rjschmidt@ucdavis.edu.
Julie B SchweitzerUC Davis MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, 2825 50th St, Sacramento, CA 95817, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California at Davis, 4610 X St, Sacramento, CA 95817, USA. Electronic address: jschweitzer@ucdavis.edu.
Anne P StarlingDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC 27599, USA; Center for Lifecourse Epidemiology of Adiposity and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: anne.starling@unc.edu.
Heather E VolkDepartment of Mental Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA. Electronic address: hvolk1@jhu.edu.
Megan L WoodburyCollege of Engineering, Northeastern University, Snell Engineering Center, 360 Huntington Ave, Boston, MA 02115, USA. Electronic address: m.woodbury@northeastern.edu.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, San Francisco, CA 94143, USA. Electronic address: tracey.woodruff@ucsf.edu.
Qi ZhaoDepartment of Preventive Medicine, University of Tennessee Health Science Center, 920 Madison Ave, Memphis, TN 38163, USA. Electronic address: qzhao11@uthsc.edu.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, 1 Kaiser Plaza, Oakland, CA 94612, USA. Electronic address: Yeyi.Zhu@kp.org.
Deborah H BennettDepartment of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, USA. Electronic address: dhbennett@ucdavis.edu.
ECHO Cohort Consortium
Funding
Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9MECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4MWisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8MThe NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5MMount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1MA prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3MThe ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7MPrenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3MECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and ProcessingU24OD035523 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Suman Ranjan Das, NATASHA Bassam HALASA · 2023 to 2026
$32.8MEnvironmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7MLifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4MThe NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5MNIEHS NIH HHS P30 ES023513NIEHS NIH HHS R24 ES028533NIEHS NIH HHS U24 ES026539NIEHS NIH HHS U24 ES028533NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026542NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030851NIEHS NIH HHS U2C ES030857NIEHS NIH HHS U2C ES030859NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U24 OD035523NIH HHS U2C OD023375NIH HHS UG3 OD023244NIH HHS UG3 OD023248NIH HHS UG3 OD023249NIH HHS UG3 OD023251NIH HHS UG3 OD023253NIH HHS UG3 OD023272NIH HHS UG3 OD023275NIH HHS UG3 OD023279NIH HHS UG3 OD023282NIH HHS UG3 OD023285NIH HHS UG3 OD023288NIH HHS UG3 OD023289NIH HHS UG3 OD023290NIH HHS UG3 OD023305NIH HHS UG3 OD023313NIH HHS UG3 OD023337NIH HHS UG3 OD023342NIH HHS UG3 OD023344NIH HHS UG3 OD023348NIH HHS UG3 OD023349NIH HHS UG3 OD023365NIH HHS UG3 OD023389NIH HHS UG3 OD035508NIH HHS UG3 OD035509NIH HHS UG3 OD035513NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035519NIH HHS UG3 OD035521NIH HHS UG3 OD035526NIH HHS UG3 OD035527NIH HHS UG3 OD035528NIH HHS UG3 OD035529NIH HHS UG3 OD035532NIH HHS UG3 OD035533NIH HHS UG3 OD035536NIH HHS UG3 OD035537NIH HHS UG3 OD035540NIH HHS UG3 OD035542NIH HHS UG3 OD035543NIH HHS UG3 OD035544NIH HHS UG3 OD035546NIH HHS UG3 OD035550NIH HHS UH3 OD023244NIH HHS UH3 OD023248NIH HHS UH3 OD023249NIH HHS UH3 OD023251NIH HHS UH3 OD023253NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023272NIH HHS UH3 OD023275NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023313NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023332NIH HHS UH3 OD023337NIH HHS UH3 OD023342NIH HHS UH3 OD023344NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIH HHS UH3 OD023389NIH HHS UH3 OD035526NIH HHS UH3 OD035550
Abstract
backgroundPrenatal exposure to organophosphate esters (OPEs) has been linked to neurotoxic effects in children; however, epidemiological evidence remains inconclusive. We investigated associations of prenatal OPE exposure with child behaviors.
methodsWe analyzed data of 2948 mother-child dyads from 12 prospective cohorts of the Environmental influences on Child Health Outcomes (ECHO) Cohort. Nine OPE biomarkers quantified in prenatal maternal urine were modeled based on detection frequency. Child behaviors were assessed using the Child Behavior Checklist for Ages 1½-5. We used linear mixed effects models to examine associations between each OPE biomarker and composite T-scores. We evaluated child sex and social vulnerability as potential effect modifiers.
resultsLow bis(butoxyethyl) phosphate exposure, versus non-detect, was associated with higher T-scores for all composite scales (β DISCUSSION: Gestational exposure to several OPEs may be adversely associated with early behavioral development.
Indexed as
Child BehaviorEnvironmental PollutantsFlame RetardantsMaternal ExposureOrganophosphatesPrenatal Exposure Delayed EffectsAdultBiomarkersChild HealthChild, PreschoolCohort StudiesEstersFemaleHumansInfantMaleBiomarkersEnvironmental PollutantsEstersFlame RetardantsOrganophosphatesExternalizing behaviorFlame retardantsInternalizing behaviorOrganophosphate estersPlasticizersPregnancy
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