Trial reportScientific reports2025
Association and predictive value of the triglyceride glucose-weight adjusted waist index for cardiovascular outcomes in patients with type 2 diabetes.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000620. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
Who cites it
3 citing papers in PubMed.
- Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the CHARLS and ELSA aging cohorts.Cardiovascular diabetology · 2026Article
- Remnant Cholesterol Inflammatory Index and Its Association With All-Cause Mortality Among General Population and Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From Two Nationwide Studies.Clinical cardiology · 2026Article
- Associations of longitudinal trajectories of triglyceride-glucose index combined with classical and novel obesity indices and cardiovascular disease: evidence from a nationwide prospective cohort study in China.Cardiovascular diabetology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the association between a novel index, TyG-WWI (triglyceride-glucose-weight-adjusted waist index), and cardiovascular outcomes and total mortality (TM) in patients with type 2 diabetes mellitus (T2DM), and evaluates its predictive value. Data from 10,092 participants in the ACCORD/ACCORDION trials were analyzed using Cox regression, restricted cubic splines (RCS), and smooth curve fitting (SCF). Subgroup and sensitivity analyses tested robustness. Predictive ability was assessed using area under curve (AUC), net reclassification index (NRI), and integrated discrimination improvement(IDI). Higher TyG-WWI was significantly associated with increased risk of major adverse cardiovascular events (MACEs), major coronary heart disease (CHD), congestive heart failure (CHF), and total mortality (TM). Per 1-SD increase in TyG-WWI, risks rose by 11% for MACEs, 8% for major-CHD, 28% for CHF, and 12% for TM. RCS and SCF identified a nonlinear association with TM, with a turning point observed at a TyG-WWI value of 96.574. Subgroup and sensitivity analyses confirmed result stability. TyG-WWI outperformed TyG alone in predictive accuracy. A significant positive linear association exists between TyG-WWI and adverse cardiovascular outcomes in T2DM patients, while a U-shaped relationship is observed with TM. TyG-WWI is an independent predictor of future cardiovascular outcomes and TM in T2DM patients.Trial registration number NCT00000620, Clinical Trial URLs: https://clinicaltrials.gov/ct2/show/NCT00000620 , Registration Date: 1999-10-27.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.