Trial reportScientific reports2025
Effect of multimodal preventive analgesia based on serratus anterior plane block and oxycodone on postoperative analgesia in elderly patients undergoing thoracoscopic lobectomy: a randomized controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Paravertebral nerve block versus combined serratus anterior plane and intercostal nerve blocks in thoracoscopic lung segment surgery in elderly: a retrospective study.Journal of cardiothoracic surgery · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Patients undergoing thoracoscopic lobectomy often experience significant postoperative pain, which is frequently inadequately managed in elderly patients due to their unique physiological characteristics. Multimodal preventive analgesia has been shown to provide satisfactory pain relief and promote early recovery. The objective is to optimize perioperative pain management in elderly patients by multimodal preventive analgesia through a combination of serratus anterior plane block (SAPB) and oxycodone. A total of 80 elderly patients with lung cancer undergoing elective uniportal video-assisted thoracoscopic lobectomy under general anesthesia were enrolled, classified as American Society of Anesthesiologists (ASA) II or III, were randomly assigned to four groups. Group M1 received ultrasound-guided SAPB with 0.375% ropivacaine combined with intravenous oxycodone. Group M2 received intravenous oxycodone. Group M3 received SAPB, while the control group (Group C) was included for comparison. The primary outcome measures included the Visual Analogue Scale (VAS) scores at rest and during coughing immediately after postoperative tracheal extubation. Secondary outcome measures comprised VAS scores at rest and during coughing at 6 h, 24 h, 48 h, and 72 h postoperatively; intraoperative remifentanil consumption; number of activations of the Patient-Controlled Intravenous Analgesia (PCIA) pump; frequency and dosage of rescue analgesia; intraoperative vasoactive drug consumption; and incidence of postoperative adverse events. The experimental groups had significantly lower VAS scores compared to the control group at all measured time points. In the M1 group, VAS scores at 6 h and 24 h after surgery were significantly lower than those in the other two experimental groups. The secondary outcomes are statistically significant differences among the four groups. Multimodal preventive analgesia based on SAPB and oxycodone can effectively reduce perioperative pain in elderly patients undergoing thoracoscopic lobectomy, decrease intraoperative and postoperative opioid consumption, and facilitate recovery.Trial registration: ChiCTR2400088399.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.