Evidence map›Paper›PMID 40628909›Full record

ArticleScientific reports2025

Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study.

Mahya Mehri Hajmir, Atieh Mirzababaei, Faezeh Abaj, Yasaman Aali, Mahsa Samadi, Khadijeh Mirzaei

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahya Mehri HajmirDepartment of Exercise and Nutrition Sciences, The George Washington University, Washington, D.C, USA.
Atieh MirzababaeiChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com.
Faezeh AbajDepartment of Nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.
Yasaman AaliDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahsa SamadiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Khadijeh MirzaeiDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. mirzaei_kh@sina.tums.ac.ir.

Funding

Tehran University of Medical Sciences and Health Services NO: IR. TUMS.VCR.REC.1398.142
6 · The paper itself

Abstract

The association between plant-based diets, obesity, cardiovascular disease (CVD), and genetic predisposition is still not fully understood. This study explored how plant-based diets interact with genetic susceptibility to atherosclerosis and body fat in 377 Iranian women aged 18 to 48 who were overweight or obese. Using a validated 147-item food frequency questionnaire (FFQ), we established three plant-based diet indices: the Plant-Based Diet Index (PDI), the Healthy Plant-Based Diet Index (hPDI), and the Unhealthy Plant-Based Diet Index (uPDI). We calculated a Genetic Risk Score (GRS) based on three body mass index (BMI)-related single nucleotide polymorphisms (SNPs) and analyzed its interaction with the PDI. Results showed that tertile 2 of the PDI had a significant negative interaction with moderate and high-risk alleles on key atherogenic factors, including the atherogenic index of plasma (AIP), triglyceride glucose (TyG), lipid accumulation product (LAP), and visceral adiposity index (VAI) (P < 0.05). A borderline negative interaction between tertile 2 of the hPDI and moderate risk alleles regarding the Body Shape Index (ABSI) was also observed (P = 0.05). Conversely, tertile 2 of the uPDI had a significant positive interaction with moderate risk alleles related to both the Castelli Risk Index I (CRI.I) and II (CRI.II) (P = 0.03). This study suggests that interactions between genetic susceptibility and plant-based diet indices are linked to atherogenic factors and body composition.

Indexed as

AtherosclerosisBody Fat DistributionDiet, VegetarianObesityOverweightAdolescentAdultBody Mass IndexCross-Sectional StudiesDiet, Plant-BasedFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansIranMiddle AgedA body shape indexAtherogenic index of plasmaBody adiposity indicesBody roundness indexLipid accumulation productPlant dietary index

Identifiers

PMID40628909
PMCPMC12238419

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.