ArticleScientific reports2025
Serotonin activates dermal papilla cells and promotes hair growth.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- In vitro and in vivo models for androgenetic alopecia drug development.Disease models & mechanisms · 2026Review
- A novel insight into the femtosecond induced nonlinear response of monoamine neurotransmitters through experimental and in silico approaches.Scientific reports · 2025Article
- Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth.Biomolecules · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a vital role in regulating behavior, mood, memory, and gastrointestinal homeostasis. Although recent studies have identified an intestine-hair follicle link, potentially implicating 5-HT, its exact relationship with hair growth remains unclear. Here we investigated the effects of serotonin signaling on hair follicle homeostasis. Gene expression analysis showed significant upregulation of hair growth-related genes in dermal papilla cells treated with 5-HT. The hair growth-promoting effects of 5-HT were examined using hair follicle organoids and hair follicle organ cultures. The addition of 5-HT to hair follicle organoids and hair follicles promoted hair shaft elongation. Similar effects were observed with sumatriptan succinate, a 5-HT receptor agonist. These results suggest that targeting serotonin signaling can advance alopecia therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.