Evidence map›Paper›PMID 40629034›Full record

Trial reportPediatric nephrology (Berlin, Germany)2026

Dialytic sodium removal in children with acute kidney injury treated with peritoneal dialysis.

Peter Nourse, Mignon McCulloch, Ashton Coetzee, Tim Bunchman, Stefano Picca, Dieter Van der Westhuizen, Andre Brooks, Hilton Heydenrych, Brenda Morrow

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter NourseDivision of Pediatric Nephrology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. peter.nourse@uct.ac.za.ORCID http://orcid.org/0000-0002-5456-4456
Mignon McCullochDivision of Pediatric Nephrology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Ashton CoetzeeDivision of Pediatric Nephrology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Tim BunchmanChildren's Hospital of Richmond, Richmond, VA, USA.
Stefano Picca *Educational ambassador for the International Society of Nephrology, Rome, Italy.
Dieter Van der WesthuizenDivision of Chemical Pathology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Andre BrooksDivision of Cardio-Thoracic Surgery, Department of Surgery, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Hilton HeydenrychDepartment of Chemical Engineering, University of Cape Town, Cape Town, South Africa.
Brenda MorrowDivision of Paediatric Critical Care, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDialytic sodium removal (DSR) is an important parameter of peritoneal dialysis (PD) adequacy. The aim of this study was to report the DSR of children with acute kidney injury (AKI) on a standard acute PD prescription and to compare it to that of children on continuous flow peritoneal dialysis (CFPD).

methodsA secondary analysis of prospectively collected data was performed from a published randomized controlled crossover trial comparing children on conventional PD and CFPD. The conventional PD prescription used: fill volume 20 mL/kg, glucose 2.5%, dwell time 45-60 min. In this study, we described and compared DSR in 15 children with AKI receiving PD and CFPD. Relative ultrafiltration through small pore (UFSP) was also described and compared.

resultsThe median (range) weight and age of patients were 5.8 (2.3-14.0) kg and 6 (0.2-14) months. Approximately 8 h of dialysis was received per patient per modality. Results were then extrapolated and expressed per day. The mean ± SD DSR on conventional PD and CFPD were 2.7 ± 6 and 8.4 ± 10 mmol /kg/day, respectively (P = 0.02). The mean ± SD sodium dialysate to plasma (D/P) ratio on conventional PD and CFPD were 0.94 ± 0.03 and 0.94 ± 0.04 mmol/mmol (P = 1.0). Mean ± SD UFSP to total UF ratios on conventional PD and CFPD were 0.82 ± 0.39 and 0.66 ± 0.51 mL/mL (P = 0.14).

conclusionsThis study adds to the limited data on DSR in children on PD for AKI. CFPD removes more salt compared to conventional PD because of increased ultrafiltration (UF). A high percentage of UF was through small pores in both modalities.

Indexed as

Acute Kidney InjuryDialysis SolutionsPeritoneal DialysisSodiumChildChild, PreschoolCross-Over StudiesFemaleHumansInfantMaleProspective StudiesTreatment OutcomeDialysis SolutionsSodiumAcute kidney injuryChildrenDialysate salt removalPeritoneal dialysis

Identifiers

PMID40629034
PMCPMC12727783

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.