Evidence map›Paper›PMID 40629038›Full record

ArticleEye (London, England)2025

Antioxidant-rich diets and glaucoma prevention: Insights from dietary oxidative balance scores in NHANES 2005-2008.

Yuqi Yang, Hong Zhang, Xun Wu, Shuimiao Jia, Shuqing Wang, Hongyan Zhou

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Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Yuqi YangDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.
Hong Zhang *Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.
Xun Wu *Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, China.
Shuimiao Jia *Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.
Shuqing WangDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China.
Hongyan ZhouDepartment of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, China. zhouhongy@jlu.edu.cn.ORCID http://orcid.org/0000-0003-4497-7246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress plays a key role in the pathogenesis of glaucoma, and by assessing the Dietary Oxidative Balance Score (DOBS), an individual's antioxidant status can be reflected. This article aims to investigate the correlation of DOBS with glaucoma using 2005-2008 NHANES data.

methodsThe cross-sectional research involved participants aged 20 years or older who finished the NHANES interview on dietary intake and the vision and eye health questionnaire. DOBS was derived from 16 dietary factors, and the self-reported glaucoma diagnosis was employed. To investigate the correlation between DOBS and glaucoma, weighted logistic regression and sensitivity analyses were carried out utilizing propensity score matching (PSM), and the potential nonlinear correlations were examined using restricted cubic spline (RCS) curves.

resultsOur study involved 4909 participants in total. Following adjustment for all covariates, logistic regression indicated that each unit increase in DOBS was linked to a 4% decrease in the risk of glaucoma (OR = 0.96, 95% CI: 0.92, 0.99, p = 0.02). Upon converting DOBS to a categorical variable, a negative correlation was found between DOBS and self-reported glaucoma in Q4 (OR = 0.39, 95% CI: 0.19, 0.79, p = 0.013) vs. Q1. RCS curves indicated that DOBS was significantly, negatively, and linearly correlated with the prevalence of glaucoma (Nonlinearity p-value = 0.493).

conclusionIn an analysis of the NHANES database, our study concluded that a higher Dietary Oxidative Balance Score (DOBS) was significantly associated with a lower prevalence of glaucoma. This suggests that an antioxidant-rich diet may help prevent glaucoma.

Indexed as

AntioxidantsDietGlaucomaOxidative StressAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesYoung AdultAntioxidants

Identifiers

PMID40629038
PMCPMC12402445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.