ArticleBMC oral health2025
Gelatin nanofibrous scaffolds containing rutin nanoparticles: physicochemical properties, antibacterial action, and anti-inflammatory effect on dental pulp stem cells.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Engineered biomaterial-based scaffolds for dentin-pulp complex regeneration: applications and biological performance-a scoping review.Odontology · 2026Review
- Seasonal Variation of a New Brazilian Greenish-Brown Propolis Type: Chemical Composition and Antioxidant, Antimicrobial, and Antileishmanial Activities.Molecules (Basel, Switzerland) · 2026Article
- Comprehensive chemical profiling of a Botanical-Infused Chinese Fortified Wine (Guogong) via UHPLC-Q-exactive orbitrap MS and HS-GC-IMS.Food chemistry: X · 2026Article
- Hydrogel microarchitecture as a regulatory cue for in vitro odontogenic differentiation.Journal of applied oral science : revista FOB · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundBacterial infection and inflammation often are the main causes of pulp-dentin complex damage and pulp necrosis. The regeneration capacity of the pulp-dentin complex is impeded by the antibacterial and anti-inflammatory limitations of existing biomaterials, that results in high rates of failure probability in vital pulp treatments. The present study investigated the antibacterial properties and anti-inflammatory effects of gelatin nanofibrous scaffolds containing rutin nanoparticles on dental pulp stem cells.
methodsgelatin nanofibrous scaffolds containing rutin nanoparticles were generated using electrospinning method. Physicochemical characterizations analysis was accomplished using scanning electron microscope (SEM), Fourier Transform Infrared (FTIR), and X-ray diffraction (XRD) methods. Antibacterial properties were tested against Enterococcus faecalis and Pseudomonas aeruginosa using the disc diffusion technique. Anti-inflammatory effects were investigated by measuring IL-6 and TNF-α levels in dental pulp stem cells (DPSCs) grown on the scaffold. Data was analyzed using independent t-test, One-way ANOVA and Tukey’s post hoc tests. The significance level was p ≤ 0.05.
resultsThe integration of rutin into the gelatin nanofibrous scaffolds was validated using FTIR and XRD studies, which was demonstrated effective crystallization and structural incorporation. The SEM results revealed the presence of consistent nanofiber networks that effectively incorporated rutin. The antibacterial tests showed notable inhibition zones of 30 mm against E. faecalis and 28 mm against P. aeruginosa. The scaffolds containing rutin demonstrated a significant decrease in IL-6 and TNF-α levels in DPSCs (p < 0.0001).
conclusionGelatin nanofibrous scaffold containing rutin nanoparticles, providing advantages concerning of both antibacterial and anti-inflammatory properties, may have potential for regenerating the pulp-dentin complex. These findings support further development of rutin-containing biomaterials for improved outcomes in vital pulp treatments.
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