ArticleEuropean journal of medical research2025
Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and cellular experimental validation.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis has been associated with an increased risk of pre-eclampsia, but the underlying mechanisms and causal relationship remain unclear. Oxidative stress has been implicated in both conditions, suggesting a potential mechanistic link.
objectivesTo investigate the causal relationship between periodontitis and pre-eclampsia and elucidate shared molecular pathways, with a focus on oxidative stress-related mechanisms.
methodsWe employed a multi-faceted approach combining Mendelian Randomization (MR) analysis, transcriptomic data mining, and in vitro experiments. MR analysis used genome-wide association study data to assess causality. Transcriptomic analysis of public data sets identified cross-talk genes and oxidative stress markers. In vitro experiments using HTR-8/SVneo trophoblast cells treated with Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) validated key findings.
resultsMR analysis revealed no significant causal relationship between periodontitis and pre-eclampsia. Transcriptomic analysis identified 31 cross-talk genes, including 10 periodontitis and pre-eclampsia (PD&PE) marker genes and 5 oxidative stress (OS) marker genes. In vitro experiments showed increased expression of OS marker genes (ARG1, FZD1, GCLC, NQO1, and TP53INP1) and elevated reactive oxygen species levels in Pg-LPS-treated trophoblast cells. Antioxidant enzymes (SOD1, CAT, Nrf2, and HO-1) and oxidase (NOX2) were also upregulated, indicating oxidative stress response.
conclusionsWhile no direct causal relationship was found, this study reveals shared molecular pathways between periodontitis and pre-eclampsia, particularly through oxidative stress mechanisms. These findings provide new insights into the periodontitis-pre-eclampsia relationship and identify potential targets for therapeutic interventions and biomarker development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.