Evidence mapPaperPMID 40630097Full record

ArticleFrontiers in endocrinology2025

Associations of night sleep duration and daytime napping with diabetic retinopathy in patients with type 2 diabetes.

Lei Xi, Xiaohui Sun, Zhimin Feng, Yanan Cao

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Lei XiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohui SunDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhimin FengDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanan CaoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The purpose of this study was to evaluate the relationship between night sleep duration, daytime napping, and diabetic retinopathy (DR) in type 2 diabetes (T2D) patients and to explore the potential mediating role of metabolic factors. Methods: In this cross-sectional, retrospective study, night sleep and napping were assessed according to the standardized questionnaire. The metabolic factors in the examination were systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and HbA1c. Multivariate logistic regression and stratified and conjoint analysis were carried out. In addition, causal mediation analysis was performed to explore the mediating role. Results: A total of 2,433 patients [mean (SD) age, 55.82 (11.66) years; 40.07% women] were included in the final analysis. The prevalence of DR was 15.95%. Compared with reference groups, patients with long sleep [odds ratio (OR), 1.31, 95% confidence interval (CI), 1.01-1.70] and long nap (1.09, 1.04-1.23) were both associated with DR, and stratified analysis showed that this association varied among different sex and diabetes duration groups. Conjoint analysis showed that patients with both long sleep and long naps had a significantly increased risk of DR (1.75, 1.13-2.71). Mediation analysis showed that metabolic factors partially mediated this association between night sleep, naps, and DR, contributing to 9.8% and 16.3% of the total effects, respectively. Conclusions: Long sleep and long nap were associated with DR, and male patients with T2D with a shorter course (<5 years) especially need to be vigilant. The effects of night sleep and naps on DR could be superimposed, and metabolic factors partially explain the underlying mechanism.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathySleepAdultAgedBlood PressureBody Mass IndexCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsSleep DurationSurveys and Questionnairesdiabetic retinopathymetabolic factorsnappingsleeptype 2 diabetes

Identifiers

PMID40630097
PMCPMC12234332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.